Evidence map›Paper›PMID 40003975›Full record

ArticleInternational journal of molecular sciences2025

Nigrostriatal Degeneration Underpins Sensorimotor Dysfunction in an Inducible Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS).

Emre Kul, Mónica Santos, Oliver Stork

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emre KulDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany.ORCID 0000-0001-6421-4057
Mónica SantosDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany.
Oliver StorkDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany.ORCID 0000-0003-4285-7507

Funding

Deutsche Forschungsgemeinschaft 3038041027; STO488/9-1 (RU5228 Syntophagy)Deutsche Forschungsgemeinschaft 362321501(RTG 2413 SynAGE)European Union 01GM1302 (Cure-FXTAS)European Union 01GM1505 (DrugFXSPreMut)
6 · The paper itself

Abstract

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by moderately expanded CGG trinucleotide repeats in the 5' untranslated region (UTR) of the

Indexed as

AtaxiaCorpus StriatumFragile X SyndromeSubstantia NigraTremorAnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1MaleMiceMice, Inbred C57BLMice, TransgenicPrepulse InhibitionSensory GatingTrinucleotide Repeat ExpansionFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1dopamineFMR1 premutationneurodegenerationnigrostriatalP90CGG mouse modelprepulse inhibitionsubstantia nigra

Identifiers

PMID40003975
PMCPMC11855849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.