Evidence map›Paper›PMID 40003959›Full record

ArticleInternational journal of molecular sciences2025

Paeoniflorin Attenuates APAP-Induced Liver Injury via Intervening the Crosstalk Between Hepatocyte Pyroptosis and NETs.

Yu-Ru Zhu, Ya-Qin Yang, Dan-Dan Ruan, Yue-Mei Que, Hang Gao, Yan-Zi Yang, Hua-Jun Zhao

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu-Ru ZhuSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Ya-Qin YangSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Dan-Dan RuanSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Yue-Mei QueSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Hang GaoAcademy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yan-Zi YangSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Hua-Jun ZhaoSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

Funding

the Key Research Project of Traditional Chinese Medicine in Zhejiang Province 2022ZZ008the National Natural Science Foundation of China 82474271the Zhejiang Chinese Medical University Research Fund Project 2021JKJNTZ001Athe Zhejiang Chinese Medical University Research Fund Project 2023JKJNTZ04
6 · The paper itself

Abstract

(1) Liver injury caused by an overdose of acetaminophen (APAP) represents a major public health concern. Paeoniflorin (PF) has been reported to have anti-inflammatory and liver-protective effects, but the underlying mechanisms remain unclear. This study aimed to investigate the effect of PF on the crosstalk between pyroptosis and NETs in AILI. (2) APAP-treated

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryExtracellular TrapsGlucosidesHepatocytesMonoterpenesPyroptosisAnimalsCoculture TechniquesGlycosidesHep G2 CellsHMGB1 ProteinHumansMaleMiceMice, Inbred C57BLAcetaminophenGlucosidesGlycosidesHMGB1 ProteinMonoterpenespeoniflorinacetaminophenliver injuryneutrophil extracellular trapspaeoniflorinpyroptosis

Identifiers

PMID40003959
PMCPMC11855121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.