Evidence map›Paper›PMID 40003949›Full record

ArticleInternational journal of molecular sciences2025

Low-Dose Docetaxel Is Effective in Reducing Atherogenic Lipids and Atherosclerosis.

Hong Y Choi, Isabelle Ruel, Shiwon Choi, Iulia Iatan, Senna Choi, Jyh-Yeuan Lee, Jacques Genest

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hong Y ChoiResearch Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.ORCID 0000-0003-2477-1128
Isabelle RuelResearch Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.ORCID 0000-0002-9491-8028
Shiwon ChoiResearch Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.ORCID 0009-0004-7286-2942
Iulia IatanResearch Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.
Senna ChoiResearch Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.ORCID 0009-0003-9116-6398
Jyh-Yeuan LeeDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0003-1799-2416
Jacques GenestResearch Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.

Funding

CIHR PJT-165924
6 · The paper itself

Abstract

High-density lipoprotein (HDL) particles form during cellular cholesterol removal, positioning HDL biogenesis as a potential strategy to combat atherosclerosis. We identified desmocollin 1 (DSC1) as a negative regulator of HDL biogenesis and discovered that docetaxel (DTX) effectively inhibits DSC1 activity. This study assessed the efficacy of DTX in reducing atherosclerosis in

Indexed as

AtherosclerosisDocetaxelLipidsAnimalsApolipoproteins EDiet, High-FatMaleMiceMice, Inbred C57BLTriglyceridesApolipoproteins EDocetaxelLipidsTriglyceridesatherosclerosischolesteroldesmocollin 1docetaxelhigh-density lipoprotein

Identifiers

PMID40003949
PMCPMC11855627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.