Evidence map›Paper›PMID 40003924›Full record

ArticleInternational journal of molecular sciences2025

MicroRNA-21 Promotes the Viability, Proliferation and Milk Fat Synthesis of Ovine Mammary Epithelial Cells by Targeting

Liyan Hu, Jiqing Wang, Zhiyun Hao, Xian Guo, Mingna Li, Xinmiao Wu, Huimin Zhen, Chunyan Ren, Yuan Zhao, Pan Yang and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liyan HuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.ORCID 0000-0001-6197-419X
Jiqing WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.ORCID 0000-0002-9811-0085
Zhiyun HaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Xian GuoLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.ORCID 0000-0003-2390-4777
Mingna LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Xinmiao WuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Huimin ZhenCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Chunyan RenCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Yuan ZhaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Pan YangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Xuanyu WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.

Funding

Basic Research Creative Groups of Gansu Province 22JR5RA829Fuxi Young Talents Fund of Gansu Agricultural University Gaufx-02Y02National Natural Science Foundation of China 32060746the Discipline Team Project of Gansu Agricultural University GAU-XKTD-2022-21the Science and Technology project of Lanzhou city 2021-1-162
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are short endogenous non-coding RNAs and play important roles in regulating mammary development and activities of ovine mammary epithelial cells (OMECs), which affect the milk yield and milk ingredient contents of ewes. We previously found that miR-21 was highly expressed in ovine mammary tissue, while the regulatory mechanisms of miR-21 underlying mammary development and lactation performance are still unclear. Accordingly, in this study, we investigated the functions of miR-21 in the activities of OMECs, and validated the target relationship of miR-21 with a predicted target gene programmed cell death 4 (

Indexed as

Apoptosis Regulatory ProteinsEpithelial CellsMammary Glands, AnimalMicroRNAsMilkRNA-Binding Proteins3' Untranslated RegionsAnimalsCell ProliferationCell SurvivalFemaleGene Expression RegulationLactationSheep3' Untranslated RegionsApoptosis Regulatory ProteinsMicroRNAsRNA-Binding ProteinsactivitymiR-21ovine mammary epithelial cellsPDCD4triglyceride

Identifiers

PMID40003924
PMCPMC11854977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.