Evidence map›Paper›PMID 40003919›Full record

ReviewInternational journal of molecular sciences2025

LCAT in Cancer Biology: Embracing Epigenetic Regulation, Immune Interactions, and Therapeutic Implications.

Manzhi Gao, Wentian Zhang, Xinxin Li, Sumin Li, Wenlan Wang, Peijun Han

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manzhi GaoDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.ORCID 0009-0006-0664-9996
Wentian ZhangDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.
Xinxin LiDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.
Sumin LiDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.
Wenlan WangDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.ORCID 0000-0003-2764-5557
Peijun HanDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.

Funding

Shaanxi Provincial Key Research and Development Program 2024SF-YBXM-6676
6 · The paper itself

Abstract

Lecithin cholesterol acyltransferase (LCAT) is a crucial enzyme in high-density lipoprotein (HDL) metabolism that is often dysregulated in cancers, affecting tumor growth and therapy response. We extensively studied

Indexed as

Epigenesis, GeneticNeoplasmsPhosphatidylcholine-Sterol O-AcyltransferaseDNA Copy Number VariationsDNA MethylationGene Expression Regulation, NeoplasticHumansPrognosisPhosphatidylcholine-Sterol O-Acyltransferasecancer metabolismepigenetic alterationsHDLimmune modulationLCATpersonalized cancer therapy

Identifiers

PMID40003919
PMCPMC11855027

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.