Evidence map›Paper›PMID 40003901›Full record

ArticleInternational journal of molecular sciences2025

The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma.

Jean-Philippe Arnault, Kimberley Chemmama, Khedidja Ferroudj, Julien Demagny, Laurence Panicot-Dubois, Antoine Galmiche, Zuzana Saidak

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jean-Philippe ArnaultService de Dermatologie, CHU Amiens, 80054 Amiens, France.
Kimberley ChemmamaService de Biochimie, Centre de Biologie Humaine, CHU Amiens, 80054 Amiens, France.
Khedidja FerroudjUR7516 CHIMERE, UFR de Médecine, Université de Picardie Jules Verne, 80054 Amiens, France.
Julien DemagnyService d'Hématologie Biologique, Centre de Biologie Humaine, CHU Amiens, 80054 Amiens, France.
Laurence Panicot-DuboisAix-Marseille Univ, INSERM 1263, INRAE 1062, C2VN, 13385 Marseille, France.ORCID 0000-0003-0848-5009
Antoine GalmicheUR7516 CHIMERE, UFR de Médecine, Université de Picardie Jules Verne, 80054 Amiens, France.ORCID 0000-0002-5836-4646
Zuzana SaidakUR7516 CHIMERE, UFR de Médecine, Université de Picardie Jules Verne, 80054 Amiens, France.ORCID 0000-0003-4629-1141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The local expression of coagulation-related genes defines the tumor coagulome. The tumor coagulome plays a pivotal role in cancer-associated thrombosis (CAT) and hemostatic complications, such as venous thromboembolism (VTE), which are frequent in patients with advanced/metastatic cancer. Genomic analyses of human tumors, such as skin cutaneous melanoma (SKCM), have unveiled the complexity of the metastatic trajectories. However, no study to date has focused on the metastatic coagulome along these trajectories. Using bulk-tumor and single-cell analyses of primary SKCM, metastastic samples and circulating tumor cells (CTCs), we explored the coagulome of SKCM along metastatic progression. We identified consistent changes in the coagulome of SKCM metastases compared to primary tumors and observed metastatic site specificity. Compared to other metastatic sites, lung metastases of SKCM had a specific coagulome with a higher expression of

Indexed as

Blood CoagulationMelanomaSkin NeoplasmsBlood PlateletsCutaneous Malignant MelanomaDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansLung NeoplasmsMaleNeoplasm MetastasisNeoplastic Cells, CirculatingSingle-Cell AnalysisThromboplastinThromboplastincancer-associated thrombosismetastasisskin cutaneous malignant melanomatumor coagulome

Identifiers

PMID40003901
PMCPMC11855523

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.