Evidence map›Paper›PMID 40003892›Full record

ArticleInternational journal of molecular sciences2025

Expanding the Genetic and Clinical Spectrum of

Daisuke Danno, Haruka Tada, Itsuki Oda, Norihito Kawashita, Makito Hirano, Shigekazu Kitamura, Shoji Kikui, Makoto Samukawa, Keisuke Yoshikawa, Yoshiyuki Mitsui and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Migraine in children and adolescents.Developmental medicine and child neurology · 2026
    Review
  2. Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daisuke DannoHeadache Center, Department of Neurology, Tominaga Hospital Japan, Osaka 556-0017, Japan.
Haruka TadaDepartment of Life Science, Faculty of Science and Engineering, Kindai University, Osaka 577-8502, Japan.
Itsuki OdaDepartment of Life Science, Faculty of Science and Engineering, Kindai University, Osaka 577-8502, Japan.
Norihito KawashitaDepartment of Life Science, Faculty of Science and Engineering, Kindai University, Osaka 577-8502, Japan.
Makito HiranoDepartment of Neurology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.
Shigekazu KitamuraDepartment of Neurology, Konan Medical Center, Kobe 658-0064, Japan.
Shoji KikuiHeadache Center, Department of Neurology, Tominaga Hospital Japan, Osaka 556-0017, Japan.
Makoto SamukawaDepartment of Neurology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.ORCID 0000-0003-3464-0754
Keisuke YoshikawaDepartment of Neurology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.ORCID 0009-0006-7168-0623
Yoshiyuki MitsuiDepartment of Neurology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.
Yoshitaka NagaiDepartment of Neurology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan.ORCID 0000-0003-1037-3129
Takao TakeshimaHeadache Center, Department of Neurology, Tominaga Hospital Japan, Osaka 556-0017, Japan.ORCID 0000-0003-2678-6956
Kazumasa SaigohDepartment of Life Science, Faculty of Science and Engineering, Kindai University, Osaka 577-8502, Japan.

Funding

Ministry of Education, Culture, Sports, Science, and Technology of Japan 22K07547
6 · The paper itself

Abstract

Familial hemiplegic migraine (FHM) is characterized by repeated episodes of reversible localized neurological deficits, in addition to headache. The aura of HM includes visual, sensory, motor, and verbal symptoms. Hemiplegic migraine (HM) is classified into non-familial sporadic HM (SHM) and familial HM (FHM). Here, we analyzed the clinical symptoms and their relevance in four Japanese patients considered to have

Indexed as

East Asian PeopleMigraine with AuraMutationNAV1.1 Voltage-Gated Sodium ChannelAdultFemaleGene FrequencyGenetic Predisposition to DiseaseHumansJapanMaleMiddle AgedMutation, MissensePedigreeNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, humanATP1A2CACNA1ADravet syndromefamilial hemiplegic migraine (FHM)SCN1Asporadic hemiplegic migraine (SHM)

Identifiers

PMID40003892
PMCPMC11855537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.