Evidence map›Paper›PMID 40003878›Full record

ArticleInternational journal of molecular sciences2025

A Novel

Christina L Elling, Allen F Ryan, Talitha Karisse L Yarza, Amama Ghaffar, Erasmo Gonzalo D V Llanes, Jennifer M Kofonow, Maria Rina T Reyes-Quintos, Saima Riazuddin, Charles E Robertson, Ma Leah C Tantoco and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christina L EllingDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Allen F RyanDepartment of Otolaryngology, School of Medicine and Veterans Affairs Medical Center, University of California San Diego, La Jolla, CA 92093, USA.
Talitha Karisse L YarzaPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Amama GhaffarDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Erasmo Gonzalo D V LlanesPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Jennifer M KofonowDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Maria Rina T Reyes-QuintosPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.ORCID 0000-0003-0469-1374
Saima RiazuddinDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Charles E RobertsonDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-4136-4121
Ma Leah C TantocoPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Zubair M AhmedDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0003-2914-4502
Abner L ChanPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Daniel N FrankDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Charlotte M ChiongPhilippine National Ear Institute, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Regie Lyn P Santos-CortezDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
Middle ear responses in Otitis MediaR01DC000129 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 1989 to 2021
$6.8M
Genetics and Functional Studies of Autosomal Recessive Neurological DisordersR01NS107428 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Saima Riazuddin · 2018 to 2026
$4.7M
Institutional Training in Otolaryngology ResearchT32DC012280 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2013 to 2026
$3.4M
Genetic and epigenomic determinants of hearing loss in Hispanic populationsR01DC019642 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SANTOS-CORTEZ, REGIE LYN PASTOR, YANG, IVANA V · 2021 to 2025
$3.4M
Genetic Epidemiology of Body Mass Index, Adiposity and Weight GainR01DK078150 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOHLKE, KAREN L. · 2007 to 2010
$2.3M
Otitis Media Susceptibility and Middle Ear Microbial Shifts due to Gene VariantsR01DC015004 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SANTOS-CORTEZ, REGIE LYN PASTOR · 2016 to 2020
$1.9M
Obesity development and CVD risk factor--Filipino womenR01HL085144 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S · 2006 to 2009
$1.9M
An Interdisciplinary Strategy for Obesity (RMI)P20RR020649 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2004 to 2006
$1.7M
Effect of Health on Education &Work in Filipino YouthR01TW005596 · FIC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S · 2001 to 2005
$1.5M
Weight, Diet, Genes and CVD Risk Factors (Hypertension and Diabetes)R01TW008288 · FIC · UNIVERSITY OF SAN CARLOS · PI MAYOL, NANETTE LEE · 2009 to 2011
$152k
BLRD VA I01 BX001205Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development grant 5I01BX001205-11FIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288NCRR NIH HHS P20 RR020649NHLBI NIH HHS R01 HL085144NIDCD NIH HHS R01 DC000129NIDCD NIH HHS R01 DC015004NIDCD NIH HHS R01 DC019642NIDCD NIH HHS T32 DC012280NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK078150NIEHS NIH HHS P30 ES010126NIH HHS 5R01DC000129-41S1NIH HHS 5R01DC015004-06S1NIH HHS 5R01DC019642-04S1NIH HHS 5T32DC012280-10S1NINDS NIH HHS R01 NS107428Philippine Council for Health Research and Development - Department of Science and Technology Balik Scientist Program
6 · The paper itself

Abstract

Otitis media is the most frequently diagnosed disease and a leading cause of hearing loss in young children. However, genetic contributors to susceptibility and pathogen-host-environment interactions in otitis media remain to be identified. Such knowledge would help identify at-risk individuals and effectively monitor, diagnose, and treat patients with otitis media. Through exome and Sanger sequencing, we identified a rare, deleterious splice variant

Indexed as

Alternative SplicingGenetic Predisposition to DiseaseOtitis MediaAnimalsChildChild, PreschoolEar, MiddleFemaleHaemophilus influenzaeHumansMaleMicePedigreemicrobiomemiddle earnasopharynxotitis mediaRNA-sequencingSLPI

Identifiers

PMID40003878
PMCPMC11855725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.