Evidence map›Paper›PMID 40003720›Full record

ArticleLife (Basel, Switzerland)2025

Multistrain Probiotics and Telomere Length in Type 2 Diabetes: A 24-Week Randomized Controlled Trial.

Venkata Chaithanya, Janardanan Kumar, Kakithakara Vajravelu Leela, Habeeb Ali Baig, Mohamed Soliman, Awwad Alenezy, Naglaa M Shalaby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Venkata ChaithanyaDepartment of Microbiology, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu 603203, Tamil Nadu, India.ORCID 0009-0006-4333-1995
Janardanan KumarDepartment of General Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu 603203, Tamil Nadu, India.ORCID 0000-0003-1355-5833
Kakithakara Vajravelu LeelaDepartment of Microbiology, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu 603203, Tamil Nadu, India.
Habeeb Ali BaigDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia.ORCID 0000-0002-5093-0623
Mohamed SolimanDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia.
Awwad AlenezyDepartment of Family and Community Medicine, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia.
Naglaa M ShalabyDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia.ORCID 0000-0003-0235-5991

Funding

SRM Institute of Science and Technology SRMIST/R/AR(A)/SERI2023/174/21-3866.
6 · The paper itself

Abstract

backgroundThis 24-week randomized controlled trial aimed to evaluate the impact of multistrain probiotic supplementation on telomere length in patients with type 2 diabetes (T2DM). The study also assessed secondary outcomes including high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c).

methodsA total of 124 participants with T2DM were randomly assigned to either a probiotic group (

resultsThe probiotic group exhibited a statistically significant decrease in telomere shortening compared to the placebo group (

conclusionsMultistrain probiotic supplementation shows potential benefits in reducing telomere shortening and improving glycemic control. However, further long-term studies are needed to understand the underlying mechanisms and therapeutic implications of probiotics in T2DM.

trial registrationThis trial was registered at the Clinical Trials Registry-India (CTRI/2023/07/055647).

Indexed as

HbA1chs-CRPprobioticstelomere lengthtype 2 diabetes

Identifiers

PMID40003720
PMCPMC11856756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.