Evidence map›Paper›PMID 40003608›Full record

ArticleLife (Basel, Switzerland)2025

Microalgae-Derived Carotenoid Extract and Biomass Reduce Viability, Induce Oxidative Stress, and Modulate the Purinergic System in Two Melanoma Cell Lines.

Luisa Chitolina Schetinger, Loren S B de Jesus, Nathieli B Bottari, Altevir R Viana, Jelson N Nauderer, Marcylene V Silveira, Milagros Castro, Pricila Nass, Patrícia Acosta Caetano, Vera Morsch and 3 more

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luisa Chitolina SchetingerDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Loren S B de JesusDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Nathieli B BottariDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Altevir R VianaDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0002-0571-4219
Jelson N NaudererDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Marcylene V SilveiraDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Milagros CastroDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0001-9274-2877
Pricila NassDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Patrícia Acosta CaetanoDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Vera MorschDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Eduardo Jacob-LopesDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Leila Queiroz ZepkaDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0002-5075-2994
Maria Rosa Chitolina SchetingerDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0002-5240-8935

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001National Council for Scientific and Technological Development 00
6 · The paper itself

Abstract

Cutaneous melanoma (CM) is an aggressive and metastatic tumor, resulting in high mortality rates. Despite significant advances in therapeutics, the available treatments still require improvements. Thus, purinergic signaling emerged as a potential pathway to cancer therapy due to its involvement in cell communication, proliferation, differentiation, and apoptosis. In addition, due to safety and acceptable clinical tolerability, carotenoids from microalgae have been investigated as adjuvants in anti-melanoma therapy. Then, this work aimed to investigate the in vitro anti-melanogenic effect of carotenoid extract (CA) and total biomass (BM) of the

Indexed as

adenosineATPcarotenoidsmelanomapurinergic system

Identifiers

PMID40003608
PMCPMC11856458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.