ArticleLife (Basel, Switzerland)2025
Microalgae-Derived Carotenoid Extract and Biomass Reduce Viability, Induce Oxidative Stress, and Modulate the Purinergic System in Two Melanoma Cell Lines.
Luisa Chitolina Schetinger, Loren S B de Jesus, Nathieli B Bottari, Altevir R Viana, Jelson N Nauderer, Marcylene V Silveira, Milagros Castro, Pricila Nass, Patrícia Acosta Caetano, Vera Morsch and 3 more
Abstract read
In one paragraphArticle in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Luisa Chitolina SchetingerDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Loren S B de JesusDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Nathieli B BottariDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Altevir R VianaDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0002-0571-4219 Jelson N NaudererDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Marcylene V SilveiraDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Milagros CastroDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0001-9274-2877 Pricila NassDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Patrícia Acosta CaetanoDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Vera MorschDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Eduardo Jacob-LopesDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.
Leila Queiroz ZepkaDepartment of Food Science and Technology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0002-5075-2994 Maria Rosa Chitolina SchetingerDepartment of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil.ORCID 0000-0002-5240-8935 Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001National Council for Scientific and Technological Development 00
6 · The paper itselfAbstract
Cutaneous melanoma (CM) is an aggressive and metastatic tumor, resulting in high mortality rates. Despite significant advances in therapeutics, the available treatments still require improvements. Thus, purinergic signaling emerged as a potential pathway to cancer therapy due to its involvement in cell communication, proliferation, differentiation, and apoptosis. In addition, due to safety and acceptable clinical tolerability, carotenoids from microalgae have been investigated as adjuvants in anti-melanoma therapy. Then, this work aimed to investigate the in vitro anti-melanogenic effect of carotenoid extract (CA) and total biomass (BM) of the
Indexed as
adenosineATPcarotenoidsmelanomapurinergic system
Identifiers
PMID40003608
PMCPMC11856458
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