Evidence map›Paper›PMID 40003604›Full record

ArticleLife (Basel, Switzerland)2025

Integrin β2 Plays a Significant Role in Therapeutic Angiogenesis Through Hematopoietic Stem Cell Transplantation.

Orie Saino, Yuko Ogawa, Kazuta Yasui, Akihiro Fuchizaki, Rie Akamatsu, Yoriko Irie, Mitsunobu Tanaka, Takafumi Kimura, Akihiko Taguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Orie SainoDepartment of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, 2-2, Minatojima-Minamimachi, Chou-Ku, Kobe 650-0047, Hyogo, Japan.ORCID 0009-0000-9872-3845
Yuko OgawaDepartment of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, 2-2, Minatojima-Minamimachi, Chou-Ku, Kobe 650-0047, Hyogo, Japan.ORCID 0000-0002-5862-4436
Kazuta YasuiJapanese Red Cross Kinki Block Blood Center, 7-5-17, Asagi Saito, Ibaraki 567-0085, Osaka, Japan.
Akihiro FuchizakiJapanese Red Cross Kinki Block Blood Center, 7-5-17, Asagi Saito, Ibaraki 567-0085, Osaka, Japan.ORCID 0000-0003-3387-1817
Rie AkamatsuDepartment of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, 2-2, Minatojima-Minamimachi, Chou-Ku, Kobe 650-0047, Hyogo, Japan.
Yoriko IrieJapanese Red Cross Kinki Block Blood Center, 7-5-17, Asagi Saito, Ibaraki 567-0085, Osaka, Japan.
Mitsunobu TanakaDepartment of Preventive Medicine and Public Health, National Defense Medical College, 3-2, Namiki, Tokorozawa 359-8513, Saitama, Japan.ORCID 0000-0002-9024-6818
Takafumi KimuraJapanese Red Cross Kinki Block Blood Center, 7-5-17, Asagi Saito, Ibaraki 567-0085, Osaka, Japan.ORCID 0000-0002-8718-2024
Akihiko TaguchiDepartment of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, 2-2, Minatojima-Minamimachi, Chou-Ku, Kobe 650-0047, Hyogo, Japan.ORCID 0000-0003-2765-4621

Funding

Japan Agency for Medical Research and Development JP21bm0404069 JP23ym0126038TERUMO LIFE SCIENCE FOUNDATION 23-Ⅲ6008
6 · The paper itself

Abstract

The efficacy of hematopoietic stem cell (HSC) therapy for cerebral infarction has been previously demonstrated. However, the lack of response in some patients has hindered its widespread use. To establish HSC therapy as a standard treatment, it is important to examine the causes of non-responsiveness. In this study, we aimed to identify the specifications of transplanted cells based on their therapeutic mechanisms to predict treatment success. We found that HSC therapy activates injured cerebral endothelial cells via gap junctions because cell adhesion between HSCs and the endothelium plays an essential role in cellular communication via gap junctions. The expression of the adhesion molecule integrin β2 (CD18) in CD34-positive (CD34

Indexed as

adhesion factorsCD18cell therapyhematopoietic stem cellintegrin β2stroke

Identifiers

PMID40003604
PMCPMC11856074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.