Evidence map›Paper›PMID 40003603›Full record

ArticleLife (Basel, Switzerland)2025

Respiratory Muscle Dysfunction and Associated Risk Factors Following COVID-19-Related Hospitalisation.

Alessia Verduri, Roberto Tonelli, Pierluigi Donatelli, Jonathan Hewitt, Giovanni Guaraldi, Jovana Milić, Valentina Ruggieri, Cristina Mussini, Enrico Clini, Bianca Beghè

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessia VerduriRespiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-7081-9383
Roberto TonelliRespiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-6202-0758
Pierluigi DonatelliRespiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Jonathan HewittDepartment of Population Medicine, Cardiff University, Cardiff CF24 4AG, UK.ORCID 0000-0002-7924-1792
Giovanni GuaraldiInfectious Diseases Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Jovana MilićInfectious Diseases Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Valentina RuggieriRespiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Cristina MussiniInfectious Diseases Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Enrico CliniRespiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-1515-5094
Bianca BeghèRespiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have highlighted long-term respiratory muscle dysfunction in COVID-19 survivors, although the underlying risk factors remain unclear. This single-centre study assessed respiratory muscle function and individual associated factors at follow-up in patients hospitalised with COVID-19 and related acute respiratory failure.

methodsData were collected for consecutive patients, aged ≥ 18 years, at the post-COVID outpatient service of Hospital Policlinico in Modena (Italy) in the time frame of 3 to 6 months after discharge. Data were analysed using single and multiple logistic regression models. Correlations among MIP/MEP, hand-grip values, and lung function were further explored.

resultsOut of 223 patients (mean age 67 years, 69% male) 121 (54.3%) exhibited MIP or MEP dysfunction, which was found to be associated with the use of non-invasive ventilation (aOR = 1.91 [1.07-3.49],

conclusionsRespiratory muscle dysfunction is consistently prevalent and parallels peripheral muscle weakness and the lung function level in patients at follow-up after severe COVID-19. The need for non-invasive ventilation during the acute phase and female gender might represent risk factors. MIP/MEP assessment should be recommended to observe respiratory muscle dysfunction in severe post-COVID survivors.

Indexed as

hand-grip strengthlung functionmaximal expiratory pressure (MEP)maximal inspiratory pressure (MIP)non-invasive ventilationpost-COVID

Identifiers

PMID40003603
PMCPMC11856529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.