Evidence map›Paper›PMID 40003592›Full record

ArticleLife (Basel, Switzerland)2025

Effects of Repetitive Transcranial Magnetic Stimulation Applied over the Primary Motor Cortex on the Offset Analgesia Phenomenon.

Elisa Antoniazzi, Camilla Cavigioli, Vanessa Tang, Clara Zoccola, Massimiliano Todisco, Cristina Tassorelli, Giuseppe Cosentino

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elisa AntoniazziTranslational Neurophysiology Research Section, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Camilla CavigioliTranslational Neurophysiology Research Section, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Vanessa TangTranslational Neurophysiology Research Section, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Clara ZoccolaTranslational Neurophysiology Research Section, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Massimiliano TodiscoTranslational Neurophysiology Research Section, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-6527-3558
Cristina TassorelliDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-1513-2113
Giuseppe CosentinoTranslational Neurophysiology Research Section, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-0309-6410

Funding

Italian Ministry of Health Ricerca Corrente 2022-2024
6 · The paper itself

Abstract

In this study, we investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left upper limb primary motor cortex (M1) on the offset analgesia (OA) phenomenon, a measure of endogenous pain modulation. In particular, we aim to determine whether rTMS influences OA differently in the forearm region, corresponding to the stimulated cortical area, compared to the trigeminal region. Twenty-two healthy volunteers underwent three experimental sessions: a baseline session without stimulation, an active rTMS session, and a sham rTMS session. Quantitative sensory testing (QST) paradigms, including warm and cold detection thresholds, heat pain threshold corresponding to a visual analogue scale (VAS) score of approximately 50-60 out of 100 (Pain

Indexed as

chronic pain managementendogenous pain modulationoffset analgesia (OA)primary motor cortex (M1)quantitative sensory testing (QST)repetitive transcranial magnetic stimulation (rTMS)somatotopic organization

Identifiers

PMID40003592
PMCPMC11856385

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.