ReviewLife (Basel, Switzerland)2025
The Role of the Claustrum in Parkinson's Disease and Vascular Parkinsonism: A Matter of Network?
Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Drug-Induced Amyloid-Related Imaging Abnormalities: A Neurovascular Perspective on Risk Assessment.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Vascular parkinsonism: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Resting-state functional connectivity of the marmoset claustrum.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms underlying extrapyramidal disorders and their anatomical substrate have been extensively investigated. Recently, the role of the claustrum in Parkinson's disease and other neurodegenerative conditions has been better detailed. The main aim of this review was to summarize the supporting evidence for the role of the claustrum in degenerative and vascular parkinsonism.
methodsThe anatomy, biology, vascular supply, and connections of the claustrum in humans were identified and described, providing the substrate for the vascular involvement of the claustrum in large- and small-vessel disease. The vascular supply of the claustrum includes up to three different sources from a single artery, the middle cerebral artery, and it is known as territory with an intermediate hemodynamic risk. The connections of the claustrum make it a sensory integrator and a relevant point in several networks, from consciousness to movement planning.
conclusionsThe claustrum is still an incompletely explained structure. However, recent description of its multiple connections indicate that it is involved in several diseases, including Parkinson's disease. The evidence underlying its potential role in vascular parkinsonism is still scarce, but it might be a field warranting future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.