Evidence map›Paper›PMID 40003582›Full record

ArticleLife (Basel, Switzerland)2025

Improved Inhibitors Targeting the Thymidylate Kinase of Multidrug-Resistant

Souleymane Konate, Koffi N'Guessan Placide Gabin Allangba, Issouf Fofana, Raymond Kre N'Guessan, Eugene Megnassan, Stanislav Miertus, Vladimir Frecer

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Souleymane KonateLaboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (Now Nangui Abrogoua), Abidjan 02, Côte d'Ivoire.
Koffi N'Guessan Placide Gabin AllangbaLaboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (Now Nangui Abrogoua), Abidjan 02, Côte d'Ivoire.
Issouf FofanaLaboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (Now Nangui Abrogoua), Abidjan 02, Côte d'Ivoire.
Raymond Kre N'GuessanLaboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (Now Nangui Abrogoua), Abidjan 02, Côte d'Ivoire.
Eugene MegnassanLaboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (Now Nangui Abrogoua), Abidjan 02, Côte d'Ivoire.ORCID 0000-0003-1505-5277
Stanislav MiertusInternational Centre for Applied Research and Sustainable Technology, 84104 Bratislava, Slovakia.ORCID 0000-0001-6766-4571
Vladimir FrecerInternational Centre for Applied Research and Sustainable Technology, 84104 Bratislava, Slovakia.ORCID 0000-0001-9378-5860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to design improved inhibitors targeting the thymidylate kinase (TMK) of

Indexed as

3D-QSAR pharmacophorein silico screeningMM-PBSAmolecular dynamicsmolecular modellingMycobacterium tuberculosisprediction of pharmacokinetic profilesQSAR model of inhibition in vitrothymidylate kinasetuberculosisvirtual combinatorial library

Identifiers

PMID40003582
PMCPMC11856008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.