Evidence map›Paper›PMID 40003574›Full record

ArticleLife (Basel, Switzerland)2025

Comparative Analysis of the Effectiveness of Generic and Brand-Name Cefepime: A Multicenter Retrospective Cohort Study.

Chih-Huang Li, Peng-Hao Chang, Ching-Tai Huang, Chip-Jin Ng

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chih-Huang LiDepartment of Emergency Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 33342, Taiwan.ORCID 0000-0002-2235-8914
Peng-Hao ChangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-7756-8484
Ching-Tai HuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chip-Jin NgDepartment of Emergency Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 33342, Taiwan.ORCID 0000-0003-0363-2938

Funding

Chang Gung Memorial Hospital CMRPG3M1031-2, CMRPG3M1811, CMRPG3P0491, CMRPG3P0871China Chemical and Pharmaceutical Co., Ltd XMRPG3N1081
6 · The paper itself

Abstract

The clinical effectiveness of generic and brand-name cefepime in real-world settings remains unclear. Given the potential implications for healthcare costs and patient outcomes, this study aims to compare the efficacy and safety of these two formulations. We conducted a multicenter, retrospective cohort study (2017-2022), enrolling adults who received either generic or brand-name cefepime as initial monotherapy for at least three consecutive days. Demographics, comorbidities, disease severity, infection sites, cefepime dosage, and serial laboratory data were analyzed. Propensity score matching was employed to adjust key confounding variables. A total of 2370 patients were included, 877 receiving generic and 1493 receiving brand-name cefepime. After matching, no significant differences were observed in primary (in-hospital mortality,

Indexed as

cefepimeeffectivenessgeneric drugsafetyseizuresepsis

Identifiers

PMID40003574
PMCPMC11856423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.