Evidence map›Paper›PMID 40003558›Full record

ArticleLife (Basel, Switzerland)2025

DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation.

Aude-Marie Lepagnol-Bestel, Simon Haziza, Julia Viard, Paul A Salin, Arnaud Duchon, Yann Herault, Michel Simonneau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aude-Marie Lepagnol-BestelCentre Psychiatrie & Neurosciences, INSERM U894, 75014 Paris, France.ORCID 0000-0002-8923-1037
Simon HazizaCentre Psychiatrie & Neurosciences, INSERM U894, 75014 Paris, France.ORCID 0000-0001-5051-8148
Julia ViardCentre Psychiatrie & Neurosciences, INSERM U894, 75014 Paris, France.
Paul A SalinCentre de Recherche en Neuroscience de Lyon CRNL (INSERM U1028), Université Claude-Bernard Lyon 1, 69100 Lyon, France.
Arnaud DuchonInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR7104, INSERM, U964, 67404 Illkirch, France.ORCID 0000-0003-3043-702X
Yann HeraultInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR7104, INSERM, U964, 67404 Illkirch, France.ORCID 0000-0001-7049-6900
Michel SimonneauCentre Psychiatrie & Neurosciences, INSERM U894, 75014 Paris, France.ORCID 0000-0003-0857-8619

Funding

European FP7-HEALTH AgedBrainSysbio and European JPND TransPathND program (to M.S.). AgedBrainSysBio TransPath
6 · The paper itself

Abstract

Chromosome 21 DYRK1A kinase is associated with a variety of neuronal diseases including Down syndrome. However, the functional impact of this kinase at the synapse level remains unclear. We studied a mouse model that incorporated YAC 152F7 (570 kb), encoding six chromosome 21 genes including

Indexed as

Down syndromeepigeneticslong-term potentiationNMDA-independent LTPpre-synaptic mechanismssynapse

Identifiers

PMID40003558
PMCPMC11856406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.