Evidence map›Paper›PMID 40003347›Full record

ArticleChildren (Basel, Switzerland)2025

The Contribution of FMRP to the Development of Speech and Vocabulary in Young Boys with Fragile X Syndrome: A Retrospective Examination.

Stephen R Hooper, John Sideris, Deborah R Hatton, Joanne R Roberts

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Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Stephen R HooperDepartment of Health Sciences, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27519, USA.ORCID 0000-0002-6761-4504
John SiderisDepartment of Occupational Therapy, University of Southern California, Los Angeles, CA 90007, USA.
Deborah R HattonFrank Porter Graham Child Development Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27519, USA.
Joanne R RobertsFrank Porter Graham Child Development Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27519, USA.

Funding

Pragmatic Skills of Young Males and Females with Fragile X SyndromeR01HD038819 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARTIN, GARY EVERETT · 2001 to 2011
$4.2M
Speech of Young Males with Fragile X SyndromeR01HD044935 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZAJAC, DAVID J · 2003 to 2012
$4.0M
Administration on Developmental Disabilities 90DD043003Maternal Child Health Bureau MCJ370599, MCJ370649, MCJ379154A, MCJ00343National Institute of Child Health and Human Development 1 R01 HD38819, 1 R01 HD044935NICHD NIH HHS R01 HD038819NICHD NIH HHS R01 HD044935
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study examined the development of speech, expressive vocabulary, and receptive vocabulary in boys with Fragile X Syndrome (FXS), with a focus on the contribution of the Fragile X Messenger Ribonucleoprotein (FMRP), while controlling for the effects of nonverbal IQ, maternal education, and Autism status on the development of these skills.

methodsParticipants included 45 boys with full mutation FXS, ranging in age from 2.9 to 14.0 years, who were subdivided into those with FXS only (FXS-Only) and those with FXS and Autism (FXS-Autism). Speech, expressive vocabulary, and receptive vocabulary skills were assessed over three years for each participant.

resultsThere was a significant relationship between each of the outcome measures and the child's nonverbal mental level, and between for both outcome measures of vocabulary and Autism status, but these relationships were moderated by the level of FMRP. Specifically, higher levels of FMRP seemed to increase the relationship between developmental level of speech, receptive, and expressive vocabulary for boys with FXS with and without Autism; however, at lower levels of FMRP, these relationships seemed to weaken significantly for both groups.

conclusionsThese findings implicate increased complexity in the relationship between various contributors to the rates of growth of speech, expressive vocabulary, and receptive vocabulary in boys with FXS, with FMRP being a key variable potentially moderating the relationship between nonverbal abilities, Autism status, and speech and vocabulary development.

Indexed as

articulationexpressive vocabularyFMRPFragile X Syndromelanguage developmentreceptive vocabularyspeech production

Identifiers

PMID40003347
PMCPMC11854059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.