ArticleChildren (Basel, Switzerland)2025
The Relationship Between Fatigue, Pain Interference, Pain-Related Distress, and Avoidance in Pediatric Hypermobile Ehlers-Danlos Syndrome.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Understanding Physical Activity Demands and Reported Perceptions of Fatigue in Children with Developmental Disabilities.Behavioral sciences (Basel, Switzerland) · 2026Article
- Knowledge, skills, and attitudinal gaps in fibrodysplasia ossificans progressiva diagnosis and management in the United States.JBMR plus · 2026Article
- Age-related symptom clustering in pediatric hypermobility spectrum disorders: a scoping review.Orphanet journal of rare diseases · 2026Article
- Characteristics of Pain in Patients Diagnosed With Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders. An Observational Study.Pain research & management · 2026Observational
- Safety and outcomes of intensive interdisciplinary pain treatment for patients with and without pediatric generalized joint hypermobility: a longitudinal retrospective study.Rheumatology international · 2025Article
- Beyond the Mainstream: Exploring Parent Protective Behaviors in Asian Families Experiencing Pediatric Chronic Pain.Children (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
BACKGROUND/
objectivesFatigue is a known predictor of disability and reduced quality of life in youth with hypermobility and chronic pain in general. Given the added relationship between chronic fatigue and connective tissue disorders, including hypermobile Ehlers-Danlos Syndrome (hEDS), this study aims to investigate the comparative role of fatigue on important predictors of outcomes for youth with and without hEDS who have chronic pain.
methodsIn this retrospective study, pediatric patients with chronic pain diagnosed with hEDS (
resultsFatigue scores were higher and clinically elevated fatigue was more prevalent in those with hEDS than in matched chronic pain peers. Fatigue was significantly positively related to pain interference, avoidance, and pain-related distress in youth with and without hEDS.
conclusionsThe current study supports the need for multidisciplinary treatment and rehabilitation for pediatric chronic pain and hypermobility and suggests that fatigue may be an important factor to consider when treating youth with hypermobility.
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