ReviewChildren (Basel, Switzerland)2025
Dental Manifestations in Children Affected by Hypophosphatemic Rickets: A Systematic Review and Meta-Analysis.
Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Macroscopic Examination of Skeletal Tissues in Phosphorus-Deficient Rainbow Trout Oncorhynchus mykiss.Journal of fish diseases · 2026Article
- Early Dental Manifestations and Multidisciplinary Management of X-Linked Hypophosphatemic Rickets in a Pediatric Patient: A Case Report.Children (Basel, Switzerland) · 2025Article
- Oral Health Status and Parental Awareness in Children with X-Linked Hypophosphatemic Rickets: A Case-Control Study.Reports (MDPI) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypophosphatemic rickets (HR) is a bone disorder affecting phosphate-calcium metabolism, with both skeletal and dental manifestations. This review aims to analyze dental manifestations of HR in children and, where possible, compare them to those in healthy children or affected adults.
methodsThe protocol was registered at PROSPERO (CRD42024596022). The study conformed to the PRISMA guidelines. Three databases were searched for studies reporting the prevalence or incidence of any dental manifestation in children with HR. Risk of bias was assessed using JBI, RoB 2.0, and ROBINS-E tools, and Stata/SE 18.0 was used for meta-analysis. Meta-regression was used to examine the effects of therapy duration and mean age on dental manifestations' prevalence. The study received no funding.
resultsA total of 1308 records were identified, with 660 screened after removing duplicates. Forty-six studies were eligible for full-text evaluation; sixteen were included in the qualitative analysis and twelve in the meta-analysis. The dental manifestations observed included dental abscesses, developmental defects of enamel and dentin, dental caries, taurodontism, and large pulp chambers. Dental abscesses were the most common manifestation, with a pooled prevalence of 0.39. Meta-regression showed no association between therapy duration and abscess occurrence but revealed a negative association between mean age and abscess prevalence.
conclusionsDental abscesses were the most frequent manifestation in children with HR. The role of therapy in improving oral health remains unclear due to insufficient data, indicating a need for further studies on the impact of HR on children's oral health.
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