Evidence map›Paper›PMID 40003245›Full record

ReviewChildren (Basel, Switzerland)2025

The Epigenetic Role of Nutrition Among Children and Adolescents: A Systematic Literature Review.

Maria Gkiouleka, Maria Karalexi, Theodoros N Sergentanis, Dimitrios Nouvakis, Stella Proikaki, Eleni Kornarou, Tonia Vassilakou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria GkioulekaMSc in Public Health, Department of Public Health Policy, School of Public Health, University of West Attica, 196 Alexandras Avenue, 11521 Athens, Greece.
Maria KaralexiDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110 Ioannina, Greece.
Theodoros N SergentanisMSc in Public Health, Department of Public Health Policy, School of Public Health, University of West Attica, 196 Alexandras Avenue, 11521 Athens, Greece.ORCID 0000-0002-9355-5528
Dimitrios NouvakisCentral Middlesex Hospital, London North West University Healthcare NHS Trust, Harrow HA1 3UJ, UK.
Stella ProikakiMSc in Public Health, Department of Public Health Policy, School of Public Health, University of West Attica, 196 Alexandras Avenue, 11521 Athens, Greece.ORCID 0009-0006-2912-7162
Eleni KornarouMSc in Public Health, Department of Public Health Policy, School of Public Health, University of West Attica, 196 Alexandras Avenue, 11521 Athens, Greece.
Tonia VassilakouMSc in Public Health, Department of Public Health Policy, School of Public Health, University of West Attica, 196 Alexandras Avenue, 11521 Athens, Greece.ORCID 0000-0002-9993-1897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesRecent research has focused on the study of the epigenetic role of nutrition as a tool which is expected to introduce new perspectives in the field of disease prevention and management. Although maternal nutrition is one of the best-studied mechanisms of epigenetic modifications of the fetus/newborn, less is known on the impact of childhood/adolescent nutrition on the regulation of epigenetic mecha-nisms after the first year of life. The aim of the present study was the assessment of the epigenetic role of nutrition in the health and development of children and adolescents.

methodsA systematic review was performed according to the Preferred Reported Items for Systematic Reviews and Meta-analyses guidelines in five databases (PubMed, Cochrane, Science Direct, Scopus, and Google Scholar) up to 31 October 2024, which yielded 17 eligible studies. The Newcastle-Ottawa Scale and the Cochrane Collabora-tion Risk of Bias-2 tool were used for the evaluation of risk of bias in observational studies and randomized trials, respectively.

resultsThree studies investigated the epi-genetic modifications due to lifestyle interventions combining changes both in diet and physical activity; the remaining 14 studies examined the role of dietary nutrients in the regulation of epigenetic mechanisms in various health conditions, such as Angelman's syndrome, parenteral nutrition in Intensive Care Units, attention deficit hyperactivity disorder, risk of cardiovascular diseases, asthma or food sensitization, obesity, insulin resistance, and type 2 diabetes or evaluated epigenetic markers as new tools for the comprehension and prediction of the participants' response to nutritional interven-tions.

conclusionsThe important impact of diet on the regulation of epigenetic mech-anisms and the expression of various genes and gene pathways could be utilized for personalized nutritional interventions in various pediatric health conditions.

Indexed as

adolescentchildepigeneticnutritionphysical activity

Identifiers

PMID40003245
PMCPMC11854644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.