ArticleAnimals : an open access journal from MDPI2025
Comparison of the Efficacy of 15- and 19-Week Chemotherapy Protocols Based on Vincristine, L-Asparaginase, Doxorubicin, and Prednisolone for Dogs with Multicentric Lymphoma.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Multicentric lymphoma is the most common type of hematopoietic neoplasm in dogs. Chemotherapeutic protocols typically consist of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). The 15- and 19-week CHOP protocols exhibit similar outcomes, indicating that a shorter treatment duration may be a feasible treatment option. However, the 19-week LHOP protocol, which uses L-asparaginase instead of cyclophosphamide, results in a longer progression-free survival and a similar survival time compared to CHOP-based chemotherapy regimens. In this study, we conducted and historically compared the efficacy of the 15- and 19-week LHOP protocols to determine whether there are any differences in efficacy. Eighteen and twenty dogs underwent the 15- and 19-week LHOP protocols, respectively. No significant differences were found in age, body weight, sex, clinical stage, substage, T-cell phenotype, hypercalcemia status, and overall response rate between the two groups. The time to progression (TTP) and lymphoma-specific survival (LSS) for the 19-week LHOP protocol were significantly longer than those for the 15-week LHOP protocol (
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