ArticleAnimals : an open access journal from MDPI2025
Glycyrrhizin Alleviates the Damage Caused by Zearalenone and Protects the Glandular Stomach of Chickens.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dietary glycyrrhizin enhances reproductive performance by improving intestinal microbiota, liver lipid metabolism and ovarian senescence in aged breeder hens.Journal of animal science and biotechnology · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Zearalenone (ZEA) is a kind of mycotoxin that widely contaminates food and feed and poses a threat to poultry farming. As a natural extract, glycyrrhizin acid (GA) has antioxidant, antibacterial, and anti-inflammatory effects. Although studies have revealed the toxic effects of ZEA on the liver, the mechanism by which GA reduces ZEA's toxic protective glandular stomach remains unclear. In order to study the therapeutic effect of GA on tissue damage caused by ZEA, we conducted in vivo and in vitro experiments to compare the expression of inflammation, oxidative stress, apoptosis, and necrosis. The results showed that ZEA can induce inflammation in tissues and cells, inducing apoptosis and necrosis. In addition, GA can alleviate the toxic effects caused by ZEA and protect cells. Dietary GA significantly increased the antioxidant capacity of glandulae and inhibited the overexpression of NFκB/IκB-α and its mediated inflammatory response. Moreover, GA decreased the expression of pro-apoptotic factors and necrosis factors, thereby alleviating apoptosis and necrosis of chicken glandular stomach cells. At present, the mechanism of ZEA damage to livers and lungs has been confirmed by studies. However, there have been no studies on GA alleviating the damage caused by ZEA to the glandular stomach. Therefore, the purpose of this study was to explore the mechanism of GA alleviating the damage caused by ZEA in the glandular stomach through in vivo and in vitro experimental comparison. The results may provide some reference for the solution of feed contamination.
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