Evidence map›Paper›PMID 40002938›Full record

ArticleBiomedicines2025

Histological Alterations and Interferon-Gamma and AKT-mTOR Expression in an Experimental Model of Achilles Tendinopathy-A Comparison of Stem Cell and Amniotic Membrane Treatment.

Guilherme Vieira Cavalcante, Rosangela Fedato, Lucia de Noronha, Seigo Nagashima, Ana Paula Camargo Martins, Márcia Olandoski, Ricardo Pinho, Aline Takejima, Rossana Simeoni, Julio Cesar Francisco and 1 more

Abstract read
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guilherme Vieira CavalcantePostgraduate Program in Health Sciences, Department of Operative Technique and Experimental Surgery, Experimental Laboratory of Institute of Biological and Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0002-0494-2308
Rosangela FedatoPostgraduate Program in Health Sciences, Experimental Laboratory of Institute of Biological and Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0002-5549-8294
Lucia de NoronhaPostgraduate Program in Health Sciences, Department of Medical Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0003-0310-7164
Seigo NagashimaPostgraduate Program in Health Sciences, Department of Medical Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0003-0069-3823
Ana Paula Camargo MartinsPostgraduate Program in Health Sciences, Department of Medical Pathology, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.
Márcia OlandoskiDepartment of Biostatics, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.
Ricardo PinhoExperimental Laboratory of Institute of Biological and Health Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0003-3116-4553
Aline TakejimaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.
Rossana SimeoniExperimental Laboratory of Institute of Biological and Health Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.
Julio Cesar FranciscoExperimental Laboratory of Institute of Biological and Health Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0003-1970-6399
Luiz César Guarita-SouzaPostgraduate Program in Health Sciences, Department of Operative Technique and Experimental Surgery, Experimental Laboratory of Institute of Biological and Health Sciences, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0003-2781-9705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achilles tendon injuries are extremely common and have a significant impact on the physical and mental health of individuals. Both conservative and surgical treatments have unsatisfactory results. The search for new therapeutic tools, using cell therapies with stem cells (SC) and biological tissues, such as amniotic membranes (AM), has proved useful for the regeneration of injured tendons.

Indexed as

Achilles tendonAKT-mTORamniotic membraneinterferon-γmononuclear stem cellstendinopathy

Identifiers

PMID40002938
PMCPMC11852843

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.