Evidence map›Paper›PMID 40002800›Full record

ArticleBiomedicines2025

Precision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection.

Kyla Frenia, Yunxiang Fu, Maria A Beatty, Kathleen C Garwood, Jeremy Kimmel, Veena Raiji, Dipanjan Pan, David Bartlett, Leanne T Labriola, Kunhong Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyla FreniaDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0009-0001-2713-918X
Yunxiang FuAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
Maria A BeattyRetina Service, Sewickley Eye Group, Sewickley, PA 15143, USA.
Kathleen C GarwoodDepartment of Decision and System Sciences, Saint Joseph's University, Philadelphia, PA 19131, USA.
Jeremy KimmelDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Veena RaijiDepartment of Ophthalmology, Rush University Medical Center, 1725 W. Harrison St., Suite 915, Chicago, IL 60612, USA.
Dipanjan PanHuck Institutes of the Life Sciences, Department(s) of Biomedical Engineering, Nuclear Engineering, Materials Science and Engineering, The Pennsylvania State University, 101 Huck Life Sciences Building, University Park, PA 16802, USA.
David BartlettAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.ORCID 0000-0003-3099-2613
Leanne T LabriolaRetina Service, Sewickley Eye Group, Sewickley, PA 15143, USA.
Kunhong XiaoAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.ORCID 0000-0002-1069-1226

Funding

Novel hematopoietic humanized mouse model to study CAR-T therapy-associated cytokine release syndromeR21OD034476 · OD · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI FAN, YONG · 2023 to 2024
$445k
NIH HHS R21 OD034476
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarker discoverycapillary collectionLC-MS/MStear biomarkertear proteomics

Identifiers

PMID40002800
PMCPMC11852441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.