ArticleBiomedicines2025
Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients.
Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Article
- Next-Generation S3-Level Clinical Practice Guidelines in Periodontology: Methodology, Current Evidence, and Future Directions.Dentistry journal · 2026Review
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- BeyondMedicina (Kaunas, Lithuania) · 2025Review
- Inflammatory Cytokine Variations After Non-Surgical Periodontal Therapy Across Periodontal Stages and Grades.Dentistry journal · 2025Article
- Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting.BMC oral health · 2025Observational
- Pro-Inflammatory Markers in Serum and Saliva in Periodontitis and Hypertension.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundChronic inflammatory disorders, such as periodontitis, may contribute to pro-hypertensive inflammation.
objectivesThis study aimed to analyze changes in parameters for periodontitis, such as periodontal inflamed surface area (PISA) and serum inflammatory markers, following non-surgical periodontal treatment in hypertensive patients.
methodsA quasi-experimental pre-and-post study was conducted, involving 42 controlled hypertensive patients with periodontitis. The patients underwent periodontal assessment and tests, including complete blood count, glucose, triglycerides, HDL-C, LDL-C, and serum levels of inflammatory biomarkers. All patients received scaling and root planning treatment in a single session and were reevaluated one month after the treatment.
resultsPost-treatment evaluations showed significant improvements in periodontal inflammation parameters, such as pocket depth, attachment level, bleeding on probing, and biofilm percentage, with statistically significant differences (
conclusionsHypertensive patients with periodontitis who underwent non-surgical periodontal treatment showed improvements in their periodontal condition, a decrease in cytokine levels such as VEGF, and reductions in PISA associated with declines in cytokines such as IL-10, IL-6, IL-12p70, IL-17A, and VEGF. These findings confirm the role of inflammation in hypertensive patients with periodontitis.
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