Evidence map›Paper›PMID 40002735›Full record

ArticleBiomedicines2025

High-Throughput Microfluidic Production of Ultrasmall Lecithin Nanoliposomes for High-Efficacy Transdermal Delivery and Skin-Aging Treatment.

Xiao Liang, Chan Lu, Fangqiao Zheng, Zhengyi Lan, Haoji Wang, Muhammad Shafiq, Xinxin Pan, Hangrong Chen, Ming Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao LiangSchool of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID 0009-0004-4046-5360
Chan LuSchool of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Fangqiao ZhengSchool of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Zhengyi LanState Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
Haoji WangSchool of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Muhammad ShafiqInnovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki-ku, Kawasaki 210-0821, Japan.ORCID 0000-0002-5887-5032
Xinxin PanSchool of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.
Hangrong ChenSchool of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID 0000-0003-0827-1270
Ming MaSchool of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID 0000-0002-1068-4528

Funding

National Natural Science Foundation of China 52472290, 52072392Student Training Program for Innovation and Entrepreneurship of Hangzhou Institute for Ad-vanced Study, UCAS CXCY20230202Youth Innovation Promotion Association CAS 2020255
6 · The paper itself

Abstract

backgroundLiposome particles with smaller sizes could increase transdermal drug delivery efficacy for enhanced skin penetration. While microfluidic methods have enabled controlled liposome synthesis, achieving efficient production of ultrasmall nanoliposomes (NLP

methodsIn this study, we employed a helical-blade-strengthened co-flow focusing (HBSCF) device to efficiently synthesize NLP

resultsLiposome formulation primarily contains unsaturated lecithin, which endows an unprecedented capacity to NLP

conclusionsThis study presents a straightforward and efficient method for the production of NLP

Indexed as

microfluidicsphotoagingskin repairtransdermal drug deliveryultrasmall nanoliposomeswound healing

Identifiers

PMID40002735
PMCPMC11853437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.