Evidence map›Paper›PMID 40002715›Full record

ArticleBiomedicines2025

Urobilin Derived from Bilirubin Bioconversion Binds Albumin and May Interfere with Bilirubin Interacting with Albumin: Implications for Disease Pathology.

Kevin I Williams, Priyanka Suryadevara, Chang-Guo Zhan, Terry D Hinds, Zachary A Kipp

Abstract read
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Bilirubin metabolism and its application in disease prevention: mechanisms and research advances.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kevin I WilliamsDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.
Priyanka SuryadevaraDepartment of Pharmaceutical Sciences and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40508, USA.
Chang-Guo ZhanDepartment of Pharmaceutical Sciences and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40508, USA.
Terry D HindsDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0002-7599-1529
Zachary A KippDrug & Disease Discovery D3 Research Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID 0000-0001-7344-7469

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular diseaseP20GM130456 · NIGMS · UNIVERSITY OF KENTUCKY · PI M. Ashfaqul Alam · 2020 to 2026
$18.7M
Novel Liver Signaling Pathways Controlling AdiposityR01DK121797 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HINDS, TERRY D · 2020 to 2024
$2.2M
Neurobehavioral mechanisms underlying xylazine and fentanyl co-use and withdrawalR01DA058933 · NIDA · UNIVERSITY OF KENTUCKY · PI Cassandra D Gipson-Reichardt, Terry D Hinds · 2023 to 2026
$2.0M
Summer Research in Environmental Health SciencesR25ES027684 · NIEHS · UNIVERSITY OF KENTUCKY · PI Kevin Joseph Pearson, Hollie Isabel Swanson · 2017 to 2026
$903k
Bilirubin Catabolism induces Plasminogen-Activator Inhibitor 1 (PAI-1) worsening Metabolic DysfunctionF31HL170972 · NHLBI · UNIVERSITY OF KENTUCKY · PI Zachary A Kipp · 2023 to 2026
$105k
NCATS NIH HHS UL1 TR001998NHLBI NIH HHS F31 HL170972NIDA NIH HHS R01 DA058933NIDDK NIH HHS R01 DK121797NIEHS NIH HHS R25 ES027684NIGMS NIH HHS P20 GM130456NIH HHS 1F31HL170972-23A1NIH HHS 1P20GM130456-24A1NIH HHS 1R01DK121797-20A1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

albuminautofluorescencebilirubin reductasebiliverdinbiliverdin reductaseheme oxygenasePPARstercobilinurobilinogen

Identifiers

PMID40002715
PMCPMC11852593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.