Evidence map›Paper›PMID 40002632›Full record

ReviewDiagnostics (Basel, Switzerland)2025

Congenital Heart Disease After Mid-Age: From the "Grown-Up" to the Elderly.

Francesca Bonanni, Chiara Servoli, Gaia Spaziani, Elena Bennati, Chiara Di Filippo, Giulia Ksenia Cirri, Marzia Giaccardi, Iacopo Olivotto, Silvia Favilli

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca BonanniACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.ORCID 0000-0002-7566-4333
Chiara ServoliACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.ORCID 0009-0000-6530-9170
Gaia SpazianiACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.ORCID 0000-0002-4697-6303
Elena BennatiACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.ORCID 0000-0003-1392-8839
Chiara Di FilippoACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.
Giulia Ksenia CirriACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.
Marzia GiaccardiDepartment of Cardiology, Santa Maria Annunziata Hospital, 50012 Florence, Italy.
Iacopo OlivottoACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.
Silvia FavilliACHD Unit, Department of Cardiology, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early surgery and improved medical care have led to the increased survival of neonates with congenital heart disease (CHD), who now commonly reach adulthood. Among adults with CHD, a growing subgroup is represented by middle-aged and even elderly patients. In this elderly population, acquired cardiac and extracardiac comorbidities represent the main cause of morbidity and mortality; the control and correction of cardiovascular risk factors or an appropriate check for extracardiac complications (such as malignancies) is therefore of paramount importance. Complications and frailty syndrome appear to occur earlier in ACHD than in the general population due to a frequent discrepancy between chronological and biological age. Multiple stressors throughout life (hemodynamic abnormalities, cardiac operations and interventional procedures, the placement of foreign materials) that result in a chronic inflammatory response are among the leading causes of premature senescence. This review is aimed at assessing the characteristics and special needs of this elderly ACHD population with a view to proposing novel models for the organization of extended care.

Indexed as

adult congenital heart diseasecomorbiditieselderlyfrailty

Identifiers

PMID40002632
PMCPMC11854712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.