Evidence map›Paper›PMID 40002625›Full record

ReviewDiagnostics (Basel, Switzerland)2025

Hyperpolarized Xenon-129 MRI: Narrative Review of Clinical Studies, Testing, and Implementation of Advanced Pulmonary In Vivo Imaging and Its Diagnostic Applications.

Jamie L MacLeod, Humam M Khan, Ava Franklin, Lukasz Myc, Yun Michael Shim

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Rapid RASER MRI.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jamie L MacLeodDivision of Pulmonary and Critical Care, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0546, USA.ORCID 0000-0002-0919-242X
Humam M KhanNorth Alabama Medical Center, 1701 Veterans Dr., Florence, Al 35630, USA.
Ava FranklinDivision of Pulmonary and Critical Care, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0546, USA.
Lukasz MycNorth Alabama Medical Center, 1701 Veterans Dr., Florence, Al 35630, USA.
Yun Michael ShimDivision of Pulmonary and Critical Care, Department of Medicine, University of Virginia, Charlottesville, VA 22908-0546, USA.ORCID 0000-0002-3780-3371

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
Hyperpolarized Xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeuticsR01HL132177 · NHLBI · UNIVERSITY OF VIRGINIA · PI QING, KUN, SHIM, YUN MICHAEL · 2017 to 2021
$3.9M
Sexual dimorphism in susceptibility to emphysematous tissue injuryR01HL167202 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANI Wang MANICHAIKUL, Yun Michael Shim · 2023 to 2026
$3.0M
Dissolved Phase Hyperpolarized Xenon-129 MRI: a novel biomarker to quantify pulmonary pathology in young healthy e-cigarette usersR01DA059660 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI John P Mugler, Yun Michael Shim · 2024 to 2026
$2.2M
Developing Hyperpolarized Gas MRI signatures to detect and manage acute cellular rejectionR01HL173369 · NHLBI · UNIVERSITY OF VIRGINIA · PI Jaime Mata, Yun Michael Shim · 2024 to 2026
$2.2M
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NHLBI NIH HHS R01 HL132177NHLBI NIH HHS R01 HL167202NHLBI NIH HHS R01 HL173369NIDA NIH HHS R01 DA059660NIH NCAT KL2TR003016NIH NCAT UL1TR003015NIH NHLBI R01HL132177NIH NHLBI R01HL167202NIH NHLBI R01HL173379NIH NIDA R01DA059660
6 · The paper itself

Abstract

Hyperpolarized xenon-129 MRI (

Indexed as

diagnostic testhyperpolarized gas MRIhyperpolarized xenon-129 MRIpulmonary diseaserespiratory disease

Identifiers

PMID40002625
PMCPMC11854573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.