Evidence map›Paper›PMID 40002531›Full record

ReviewBrain sciences2025

Use of Carbon Fiber Implants to Improve the Safety and Efficacy of Radiation Therapy for Spine Tumor Patients.

Fred C Lam, Santosh Guru, Deyaldeen AbuReesh, Yusuke S Hori, Cynthia Chuang, Lianli Liu, Lei Wang, Xuejun Gu, Gregory A Szalkowski, Ziyi Wang and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Fred C LamDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Santosh GuruDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Deyaldeen AbuReeshDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yusuke S HoriDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cynthia ChuangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lianli LiuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-1095-0953
Lei WangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xuejun GuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gregory A SzalkowskiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ziyi WangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christopher WohlersDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Armine TayagDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sara C EmrichDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Louisa UstrzynskiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Corinna C ZygourakisDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-1894-9252
Atman DesaiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Melanie Hayden GephartDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
John ByunDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Erqi Liu PollomDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Elham RahimyDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Scott SoltysDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-5360-7063
David J ParkDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9858-2592
Steven D ChangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current standard of care treatment for patients with spine tumors includes multidisciplinary approaches, including the following: (1) surgical tumor debulking, epidural spinal cord decompression, and spine stabilization techniques; (2) systemic chemo/targeted therapies; (3) radiation therapy; and (4) surveillance imaging for local disease control and recurrence. Titanium pedicle screw and rod fixation have become commonplace in the spine surgeon's armamentarium for the stabilization of the spine following tumor resection and separation surgery. However, the high degree of imaging artifacts seen with titanium implants on postoperative CT and MRI scans can significantly hinder the accurate delineation of vertebral anatomy and adjacent neurovascular structures to allow for the safe and effective planning of downstream radiation therapies and detection of disease recurrence. Carbon fiber-reinforced polyetheretherketone (CFR-PEEK) spine implants have emerged as a promising alternative to titanium due to the lack of artifact signals on CT and MRI, allowing for more accurate and safe postoperative radiation planning. In this article, we review the tenants of the surgical and radiation management of spine tumors and discuss the safety, efficacy, and current limitations of CFR-PEEK spine implants in the multidisciplinary management of spine oncology patients.

Indexed as

carbon fiber PEEK pedicle screwscyberknifegammaknifeneuro-oncologyneurosurgeryproton beam radiation therapySBRTspine metastasisspine oncologyspine surgeryspine tumorsstereotactic radiosurgerytitanium pedicle screws

Identifiers

PMID40002531
PMCPMC11852773

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.