ReviewBrain sciences2025
The Place of Local Field Potentials in Deep Brain Stimulation Programming for Parkinson's Disease: A Review.
Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.NPJ Parkinson's disease · 2026Article
- Review
- Neuromodulation in Parkinson's disease with transcranial pulse stimulation: evidence of clinical efficacy and cortical oscillatory changes.Journal of neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Objections: The pharmacological management of Parkinson's Disease (PD) is often supplemented by deep brain stimulation (DBS) to tackle problems of advanced disease such as motor fluctuation, dyskinesias or medication-resistant tremor. DBS uses high-frequency stimulation with spatially distributed electrodes to produce electrical fields that influence neuronal networks. The programming of such stimulation is complex and time-consuming. Recent technological advancements have enabled DBS systems to record local field potentials (LFPs). In conjunction with biomarker discovery, such as beta oscillations, this shows promise in streamlining the DBS programming process. This review aims to synthesize the current literature investigating LFP characteristics in PD in order to understand the place of LFPs in assisting with DBS programming.
methodsA comprehensive literature search was conducted using databases including OVID MEDLINE, Scopus, and Cochrane Library, resulting in 738 identified articles; 122 studies remained after screening and 87 studies were selected for detailed analysis.
resultsAnalyzing LFPs clearly has the potential to assist or streamline DBS programming in clinical practice, but there are knowledge gaps and challenges to overcome, especially in the utilization of intraoperative LFPs.
conclusionsMore research is required to compare different algorithms that utilize LFPs in DBS programming to identify a simple, practical and time-saving algorithm incorporating reliable LFP biomarkers that will enhance the DBS programming experience for both patients and clinicians.
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Registered trials
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