ReviewBrain sciences2025
The Functional Origin of Oral Word Production Deficits in the Logopenic Variant of Primary Progressive Aphasia: A Systematic Review.
Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
BACKGROUND/
objectivesOral word production (OWP) deficits are prominent in the logopenic variant of primary progressive aphasia (lvPPA); however, their functional origin remains unclear. Some studies suggest a lexical, post-lexical, or even a combined functional origin of these deficits. The aim of the present study was to synthesize and analyze the information on the functional origin of the OWP deficits in patients with lvPPA.
methodsA quantitative systematic literature review was carried out using four databases: CINAHL, PsycINFO, Linguistics and Language Behavior Abstracts, and PubMed. Fourteen studies, including a total of 243 patients with lvPPA, and reporting results on picture naming and/or word and/or pseudoword repetition, were selected.
resultsThe overall findings of this review highlighted that two main functional origins appear to explain the OWP deficits in lvPPA: a lexical impairment affecting lexical processing and a post-lexical impairment affecting phonological short-term memory. Interestingly, the possibility of a third functional origin, affecting the semantic processing level, was also suggested by some studies.
conclusionsWe concluded that the presence of different functional origins of OWP in this population may be explained, at least partially, by the diversity of assessment tasks used in studies and the varied manipulation and control of psycholinguistic properties of words (e.g., frequency, length), as well as the various interpretations and analyses of the participants' errors. Further studies are needed to substantiate these findings by examining all the components involved in OWP, carefully manipulating the psycholinguistic properties and qualitatively analyzing the errors made by lvPPA participants.
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