ArticleBrain sciences2025
Neural Activity for Uninvolved Knee Motor Control After ACL Reconstruction Differs from Healthy Controls.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Distinct Movement-Related Cortical Control Following Anterior Cruciate Ligament Injury: A Scoping Review.Sports medicine - open · 2026Review
- Exploratory EEG-TMS Study Reveals Altered Behavioral Function in Individuals Following Anterior Cruciate Ligament Reconstruction.Brain sciences · 2026Article
- Postural control characteristics as reflected by center of pressure measurements in anterior cruciate ligament reconstruction patients at varying post-operative stages: a cross-sectional comparative study.Journal of orthopaedic surgery and research · 2026Article
- How Can We Optimize a Safe Return to Sport for Youth Athletes? Emerging Concepts and Perspectives - Multidisciplinary Approach.Open access journal of sports medicine · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Recovery from anterior cruciate ligament reconstruction (ACLR) induces bilateral functional and physiological adaptations. Neurophysiologic measures of motor control have focused on the involved knee joint, limiting understanding regarding the extent of bilateral neural adaptations. Therefore, the aim of this study was to investigate differences in neural activity during uninvolved-limb motor control after ACLR compared to healthy controls.
methodsFifteen participants with left ACLR (8 female and 7 male, 21.53 ± 2.7 years, 173.22 ± 10.0 cm, 72.15 ± 16.1 kg, Tegner 7.40 ± 1.1, 43.33 ± 33.1 mo. post-surgery, 2 patellar tendon, and 13 hamstring) and 15 matched controls (8 female, 23.33 ± 2.7 years, 174.92 ± 9.7 cm, 72.14 ± 15.4 kg, Tegner 7.33 ± 1.0) participated. Neural activity was evaluated using functional magnetic resonance imaging on a 3T Siemens Magnetom scanner during four 30-s cycles of a right (uninvolved) knee flexion-extension task paced with a metronome (1.2 Hz) and was completed interspersed with 30 s of rest. A significance threshold of
resultsThe ACLR group had greater neural activity in one statistically significant cluster corresponding to the left middle frontal gyrus (MFG) (834 voxels, z = 3.81,
conclusionsThese data indicate a potential contribution to uninvolved-knee neuromuscular deficits after injury and support the limitations of using the uninvolved side as a clinical reference. Uninvolved knee motor control after ACLR may require greater cognitive demand. Clinicians should be aware that the uninvolved limb might also demonstrate whole brain alterations limiting clinical inference from functional symmetry.
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