Evidence map›Paper›PMID 40002328›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Brazilian Stingless Bee Geopropolis Exhibit Antioxidant Properties and Anticancer Potential Against Hepatocellular Carcinoma Cells.

Mariana Muniz da Paz, Kamila Marques Sette, Raissa Eduardo Dos Santos, Ana Luiza Barbosa E Vasconcelos, Danielly C Ferraz da Costa, Ana Claudia F Amaral, Igor Almeida Rodrigues, Luciana Pereira Rangel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Geopropolis fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Microorganisms · 2025
    Review
  5. ACS omega · 2025
    Article
  6. Molecules (Basel, Switzerland) · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariana Muniz da PazPrograma de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Kamila Marques SettePrograma de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Raissa Eduardo Dos SantosPrograma de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Ana Luiza Barbosa E VasconcelosPrograma de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
Danielly C Ferraz da CostaInstituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-013, RJ, Brazil.ORCID 0000-0002-3149-2621
Ana Claudia F AmaralFarmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro 21041-000, RJ, Brazil.
Igor Almeida RodriguesFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-9432-3991
Luciana Pereira RangelFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0002-6154-0815

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 465395/2014-7Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.002128/2019Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.002430/2019Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.100627/2018Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.324/2021Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/203.298/2017Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/211.368/2021Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro SEI-260003/001131/2020
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the third most common cancer in terms of mortality and the sixth in incidence worldwide. Treatment varies by tumor stage, but low survival rates are common across all stages. Due to these poor outcomes, there is a critical need for new treatment options and lead compounds, prompting an active search. Geopropolis has been identified as a source of bioactive compounds with various pharmacological activities, including anticancer effects against different types of cancer. Since stingless bees may be selective for native botanical species, the geopropolis they produce can have an unusual chemical profile. In this study, we report the antioxidant properties and anticancer potential of geopropolis extracts produced by

Indexed as

anticancerantioxidanthepatocellular carcinomaMelipona bicolorMelipona marginataMelipona mondury

Identifiers

PMID40002328
PMCPMC11851454

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.