Evidence map›Paper›PMID 40002321›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Prophylactically Feeding Manganese to

Robert P Volpe, Aditya Sen, Ajay Sharma, Venkatesan Kathiresan, Brian M Hoffman, Rachel T Cox

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert P VolpeDepartment of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814, USA.ORCID 0000-0003-2784-0168
Aditya SenDepartment of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814, USA.
Ajay SharmaDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0829-6753
Venkatesan KathiresanDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-4151-9154
Brian M HoffmanDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3100-0746
Rachel T CoxDepartment of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, MD 20814, USA.ORCID 0000-0002-1945-0541

Funding

Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
Clu forms a dynamic new ribonucleoprotein particle directly involved in mitochondrial functionR01GM127938 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI COX, RACHEL TAFEL · 2019 to 2022
$1.3M
Identifying the radioprotective potential of radiation-resistant fungi using DrosophilaR21OD034471 · OD · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI COX, RACHEL TAFEL · 2024 to 2025
$439k
NIGMS NIH HHS R01 GM111097NIGMS NIH HHS R01 GM127938NIH HHS OD034471, GM127938, GM111097NIH HHS R21 OD034471
6 · The paper itself

Abstract

Ionizing radiation is a health threat to many, including warfighters, radiological emergency responders, radiotherapy patients, and astronauts. Despite this, no FDA-approved prophylactic medical countermeasures exist to attenuate the symptoms that occur from radiation exposure. Manganese has recently been shown to be critical for radioresistance in a wide range of organisms. In this study, we designed a stringent feeding method to test the prophylactic effects of dietary manganese on

Indexed as

Drosophilaelectron-nuclear double resonance (ENDOR)electron paramagnetic resonance (EPR)ionizing radiationlifespanmanganeseradiation protectionSOD2

Identifiers

PMID40002321
PMCPMC11851552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.