Evidence map›Paper›PMID 40002309›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Evaluation of Residues of Amazonian Fruit Piquia (

Izadora de Souza, Gabriella C P Grimmelprez, Klenicy K L Yamaguchi, Johannes Schleusener, Silke B Lohan, Martina C Meinke, Lorena R Gaspar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Izadora de SouzaSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Vila Monte Alegre, Ribeirao Preto 14040-900, SP, Brazil.ORCID 0000-0003-2356-9315
Gabriella C P GrimmelprezSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Vila Monte Alegre, Ribeirao Preto 14040-900, SP, Brazil.
Klenicy K L YamaguchiInstitute of Health and Biotechnology, Federal University of Amazonas, Coari 69460-000, AM, Brazil.
Johannes SchleusenerDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Silke B LohanDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0001-8156-0074
Martina C MeinkeDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Lorena R GasparSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Vila Monte Alegre, Ribeirao Preto 14040-900, SP, Brazil.

Funding

CAPES/PRINT 88887.572028/2020-00Conselho Nacional de Pesquisa 465687/2014-8Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88882.328406/2019-01Fundação de Amparo à Pesquisa do Estado de São Paulo 14/50928-2
6 · The paper itself

Abstract

Amazonian fruit residues like piquia shells are often discarded despite their antioxidant potential for sustainable cosmetic use. This study evaluated the photostability, phototoxicity, and photoprotection of hydroalcoholic piquia shell extract (PqSE) combined with UV filters in solutions and cosmetic formulations. PqSE formulations were photostable, even stabilizing photounstable UV filters. Phototoxicity tests (OECD TG 432) showed no phototoxic potential (MPE < 0.15) and reduction in the phototoxic potential of UV filters, while ocular irritation potential via HET-CAM assay indicated no irritant effects. The extract combined with UV filters enhanced protection against UVA-induced reactive oxygen species (ROS) production, achieving 60.9% effectiveness, outperforming commercial photostabilizers. Against UVB radiation, it showed cellular viability above 80%, comparable to benzophenone-3. PqSE formulations exhibited a radical protection factor (RPF) nine times higher than controls and reduced radical production by 64% after visible/near-infrared (VIS/NIR) irradiation on porcine skin, compared to 38% for controls. Confocal Raman microspectroscopy showed penetration depths below 12 µm for all time points. This study highlights the potential of reusing fruit residues like PqSE as sustainable, effective ingredients in sunscreen formulations, offering enhanced photoprotection and reduced environmental waste.

Indexed as

amazonian fruit residuesconfocal Raman microspectroscopycumulative radical production induced by VIS + NIRelectron paramagnetic resonance spectroscopynatural photostabilizerpiquia shell extractUVA and UVB protection potential

Identifiers

PMID40002309
PMCPMC11852122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.