Evidence map›Paper›PMID 40002264›Full record

ReviewCancers2025

Cardiac Tumors Causing Sudden Cardiac Death: A State-of-the-Art Review in Pathology.

Cecilia Salzillo, Stefano Lucà, Andrea Ronchi, Renato Franco, Giulia Iacobellis, Alessia Leggio, Andrea Marzullo

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Arrhythmic risk in ventricular cardiac tumors: A comparative imaging and clinical analysis.American heart journal plus : cardiology research and practice · 2026
    Article
  2. Article
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  4. Article
  5. Article
  6. Left atrial primary intimal sarcoma mimicking myxoma: case report.European heart journal. Case reports · 2026
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cecilia SalzilloDepartment of Experimental Medicine, PhD Course in Public Health, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0009-0002-7531-3178
Stefano LucàDepartment of Experimental Medicine, PhD Course in Public Health, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Andrea RonchiPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Renato FrancoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giulia IacobellisRadiology Unit, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.ORCID 0009-0007-8972-7837
Alessia LeggioLegal Medicine Unit, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-2554-1845
Andrea MarzulloPathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0003-1265-3685

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac tumors (CTs), although rare, can be a significant cause of sudden cardiac death (SCD), particularly when not diagnosed early. The tumors most associated with SCD include myxomas, fibromas, rhabdomyomas, and sarcomas, which can cause fatal arrhythmias, blood flow obstruction, or embolization. Myxomas, which often develop in the left atrium, can cause valvular obstruction or cerebral emboli, while malignant tumors, such as sarcomas, can infiltrate the myocardium or conduction system, causing serious arrhythmias. Rhabdomyomas, which are common in children and associated with tuberous sclerosis, can lead to ventricular tachyarrhythmias. Early diagnosis using advanced imaging techniques such as echocardiography and magnetic resonance imaging is crucial for preventing SCD. Timely diagnosis and precise characterization of lesions can help reduce the risk of SCD, thus improving the clinical management of patients, with the aim of supporting personalized treatment and improving life prospects. In this state-of-the-art review, we analyze the association between CTs and SCD, with particular attention to the histological features of benign and malignant neoplasms. Through an updated overview of the pathological aspects, we aim to improve the understanding of these tumors and promote a more effective multidisciplinary diagnostic and therapeutic approach to prevent fatal events.

Indexed as

benign tumorscardiac tumorsmalignant tumorssudden cardiac death

Identifiers

PMID40002264
PMCPMC11853695

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.