Evidence map›Paper›PMID 40002190›Full record

ArticleCancers2025

Patterns of Treatment Delay in Patients with Symptomatic Metastatic Epidural Spinal Cord Compression.

Shilin Wang, James T P D Hallinan, Cherie Lin Hui Tan, Khye Gin Eugene Chua, Alex Quok An Teo, Naresh Kumar, Gabriel Liu, Hwee Weng Dennis Hey, Joseph Thambiah, Leok-Lim Lau and 3 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Diagnostic errors in spinal metastases: a systematic review of contributing clinical and systemic factors.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shilin WangDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.
James T P D HallinanDepartment of Diagnostic Imaging, National University Hospital, National University Health System, Singapore 119074, Singapore.ORCID 0000-0002-0082-9033
Cherie Lin Hui TanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.
Khye Gin Eugene ChuaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.ORCID 0009-0006-1436-1968
Alex Quok An TeoDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.ORCID 0000-0002-0200-3331
Naresh KumarDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.ORCID 0000-0003-4538-5031
Gabriel LiuDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.
Hwee Weng Dennis HeyDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.ORCID 0000-0002-2012-9835
Joseph ThambiahDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.
Leok-Lim LauDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.ORCID 0000-0003-3512-2844
Hee-Kit WongDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.ORCID 0000-0003-1176-1238
Yiong-Huak ChanBiostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.ORCID 0000-0002-5076-5269
Jiong Hao Jonathan TanDepartment of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore 119074, Singapore.

Funding

Singapore Ministry of Health (MOH) National Medical Research Council (NMRC) CIAINV23jan-0001, MOH-001405
6 · The paper itself

Abstract

backgroundDelays in the diagnosis and treatment of metastatic epidural spinal cord compression (MESCC) can potentially result in serious, deleterious effects on patient outcomes and postoperative morbidity. Delays may occur any at any step in the chain of care, increasing the risk of preventable complications.

objectivesThis study, thus, aims to identify patterns of treatment delays and determine the predictive factors of postoperative ambulatory function in patients with symptomatic MESCC.

methodsAdult patients, aged >18 years, who underwent surgical treatment for MESCC between 2015 and 2022, were included for analysis in this retrospective study.

resultsA total of 177 patients were included. The most significant delay contributing to total delay was patient delay (mean duration 41 days) followed by diagnostic delay (mean duration 16 days). Patients presenting acutely to the Emergency Department and patients with neurological deficits were found to have significantly shorter delays. Preoperative neurological deficits (

conclusionsThe results of this study highlight the need for increasing patient education, enhancing physician management of patients with MESCC, and improving diagnostic efficiency to reduce delays and maximize patient outcomes.

Indexed as

compressioncorddelayfunctionindependenceMESCCmetastasesoutcomesspinetreatment

Identifiers

PMID40002190
PMCPMC11852822

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.