Evidence map›Paper›PMID 40002063›Full record

ArticleFoods (Basel, Switzerland)2025

Anti-Inflammatory Potential of Wampee (

Kaijie Shang, Zhiheng Zhao, Hua Chen, Xiaonan Bian, Xianquan Zhong, Xiaoping Hu, Xue Lin, Lu Wang

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Modulatory Effects ofNutrients · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaijie ShangSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Zhiheng ZhaoSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Hua ChenSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Xiaonan BianSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Xianquan ZhongSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Xiaoping HuSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Xue LinSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.
Lu WangSchool of Food Science and Engineering, Hainan University, Haikou 570228, China.

Funding

Hainan Provincial Natural Science Foundation of China 321RC1030Hainan Provincial Natural Science Foundation of China 321RC1075National Natural Science Foundation of China 32060513National Natural Science Foundation of China 32460562
6 · The paper itself

Abstract

The consumption of wampee has traditionally been utilized to alleviate gastrointestinal inflammation and associated disorders; however, its exact mechanism has remained unknown. The aim of this study was to elucidate the therapeutic efficacy and underlying mechanism of wampee polyphenol extract (WPE) in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). The findings revealed that WPE alleviated diverse symptoms of UC, regulated various inflammatory cytokines, and effectively protected the colon tissue structure and barrier integrity, thereby inhibiting LPS translocation. Moreover, WPE restored the richness and diversity of gut microbiota and optimized its structure at the phylum and genus levels, causing a notable improvement in short- chain fatty acid (SCFA) metabolism, particularly acetic acid, propionic acid, and butyric acid. Consequently, WPE was demonstrated to effectively suppress the LPS-induced TLR4-p38 MAPK/NF-κB signaling pathway by modulating gut microbiota and SCFA metabolism. These findings provided a theoretical basis for the use of wampee as a potential functional natural food for UC.

Indexed as

gut microbiotashort chain fatty acidssignaling pathwayulcerative colitiswampee

Identifiers

PMID40002063
PMCPMC11854079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.