Evidence map›Paper›PMID 40002056›Full record

ArticleFoods (Basel, Switzerland)2025

Comprehensive Profiling of Free Proteinogenic and Non-Proteinogenic Amino Acids in Common Legumes Using LC-QToF: Targeted and Non-Targeted Approaches.

Bharathi Avula, Kumar Katragunta, Iffat Parveen, Kiran Kumar Tatapudi, Amar G Chittiboyina, Yan-Hong Wang, Ikhlas A Khan

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bharathi AvulaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-8656-9526
Kumar KatraguntaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-8787-4602
Iffat ParveenNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0001-7272-839X
Kiran Kumar TatapudiNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Amar G ChittiboyinaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-7047-5373
Yan-Hong WangNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0003-3341-8991
Ikhlas A KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0001-5464-4643

Funding

FDA HHS U01 FD004246United States Department of Agriculture, Agricultural Research Service 58-6060-6-015US Food and Drug Administration 5U01FD004246
6 · The paper itself

Abstract

Legumes, a dietary staple for centuries, have seen an influx of conventional and unconventional varieties to cater to human care conscious consumers. These legumes often undergo pretreatments like baking, soaking, or boiling to mitigate the presence of non-proteinogenic amino acids (NPAAs) and reduce associated health risks. The recent tara flour health scare, linked to the NPAA baikiain, emphasizes the need for robust analytical methods to ensure the safety and quality of both traditional and novel plant-based protein alternatives. While traditional techniques provide insights into protein and non-proteinogenic amino acid profiles, modern liquid chromatography-mass spectrometry (LC-MS) offers superior sensitivity and specificity for NPAA detection. This study employed an LC-QToF method with MS/MS analysis to comprehensively map the distribution of free NPAAs and proteinogenic amino acids (PAAs) in various legume samples. A total of 47 NPAAs and 20 PAAs were identified across the legume samples, with at least 7-14 NPAAs detected in each sample. Sulfur-containing NPAAs, such as

Indexed as

derivatizationLC-QToF-MSnon-proteinogenic amino acidsplant-based proteinssoluble protein profiles

Identifiers

PMID40002056
PMCPMC11854323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.