Evidence map›Paper›PMID 40001950›Full record

ReviewBiology2025

Extracellular Vesicles as Biomarkers in Infectious Diseases.

Cinthia Gonzalez Cruz, Husain M Sodawalla, Thalachallour Mohanakumar, Sandhya Bansal

Abstract readReview
In one paragraph

Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Engineering Microbial Particles for Next-Generation Biomedical Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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  10. Early cancer diagnosisWorld journal of gastrointestinal oncology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cinthia Gonzalez CruzBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.ORCID 0009-0005-1321-2111
Husain M SodawallaDepartment of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ 86011, USA.ORCID 0000-0002-3580-2308
Thalachallour MohanakumarNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.ORCID 0000-0001-9873-4018
Sandhya BansalNorton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.ORCID 0000-0003-0630-9175

Funding

Chronic Lung Allograft Dysfunction: Role for Tumor Suppressor LKB1 in ExosomesR01HL156891 · NHLBI · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI THALACHALLOUR MOHANAKUMAR · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL156891
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are nanosized vesicles that are secreted by all cells into the extracellular space. EVs are involved in cell-to-cell communication and can be found in different bodily fluids (bronchoalveolar lavage fluid, sputum, and urine), tissues, and in circulation; the composition of EVs reflects the physiological condition of the releasing cell. The ability to use EVs from bodily fluids for minimally invasive detection to monitor diseases makes them an attractive target. EVs carry a snapshot of the releasing cell's internal state, and they can serve as powerful biomarkers for diagnosing diseases. EVs also play a role in the body's immune and pathogen detection responses. Pathogens, such as bacteria and viruses, can exploit EVs to enhance their survival and spread and to evade detection by the immune system. Changes in the number or contents of EVs can signal the presence of an infection, offering a potential avenue for developing new diagnostic methods for infectious diseases. Ongoing research in this area aims to address current challenges and the potential of EVs as biomarkers in diagnosing a range of diseases, including infections and infectious diseases. There is limited literature on the development of EVs as diagnostic biomarkers for infectious diseases using existing molecular biology approaches. We aim to address this gap by reviewing recent EV-related investigations in infectious disease studies.

Indexed as

biomarkersdisease detectionextracellular vesicles

Identifiers

PMID40001950
PMCPMC11851951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.