In one paragraphArticle in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Lucas P J SaavedraDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0003-0825-426X Flávio A FranciscoDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0001-5481-047X Scarlett R RaposoDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0003-2685-420X Keilah V N CavalcanteDepartment of Physiological Sciences, Federal University of Goiás, Goiânia 74690-900, GO, Brazil.ORCID 0000-0002-0410-2528 Nilza C ButtowDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-7228-7990 Stephanie C BorgesDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-2534-143X Rodrigo M GomesDepartment of Physiological Sciences, Federal University of Goiás, Goiânia 74690-900, GO, Brazil.ORCID 0000-0002-9012-3287 Hericles M CamposDepartment of Pharmacology, Federal University of Goiás, Goiânia 74690-900, GO, Brazil.ORCID 0000-0001-8032-3771 Gessica D GonçalvesDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0003-3180-5437 Silvano PiovanDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.
Paulo C GhediniDepartment of Pharmacology, Federal University of Goiás, Goiânia 74690-900, GO, Brazil.
Kelly V PratesDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-6031-8219 Ananda MaltaDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-1014-1224 Paulo MatafomeInstitute of Physiology and Institute of Clinical and Biomedical Research, Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3000-447 Coimbra, Portugal.ORCID 0000-0002-3422-290X Paulo C F MathiasDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.
Douglas L AlmeidaDepartment of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-1596-9821 Funding
National Council for Scientific and Technological Development 151389/2024-1This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento Pessoal de Nível Superior (CAPES); "It's good to do good" -JBS; Portuguese Science and Technology Foundation (FCT) UIDB/04539/2020 and UIDBP/04539/2020 (CIBB)
6 · The paper itselfAbstract
backgroundAdvanced glycation end-products (AGEs) are linked to the development of oxidative stress, insulin resistance, and impaired insulin secretion. Adverse early life conditions, such as exposure to AGEs and their precursors, may lead offspring to the development of metabolic dysfunction in adulthood. Nonetheless, the early impact in offspring metabolism by maternal intake of AGEs precursors during lactation is not known.
objectiveInvestigate early life metabolism of the offspring whose breastfeeding dams were orally exposed to AGEs precursor.
methodsBreastfeeding Wistar rats were daily treated with the glycation precursor methylglyoxal (MG-60 mg/kg of bodyweight) by gavage or saline 0.9% control (CO) until weaning. In vivo glycemic homeostasis in male offspring was assessed, followed by euthanasia for tissue sample collection for ex vivo assessments.
resultsAt weaning, MG offspring presented decreased bodyweight (
conclusionsThe consumption of AGE precursors by breastfeeding dams impaired offspring pancreatic function and glycemic homeostasis early in life.
Indexed as
advanced glycation end productsbreastfeedingdevelopmental plasticityglycemia homeostasismetabolism
Identifiers
PMID40001928
PMCPMC11851399
What OpenQuestion holds
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LicenceCC BY
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