Evidence map›Paper›PMID 40001905›Full record

ArticleBiology2025

PPARγ Expression in Human Spermatozoa and Its Relationship with Seminal F

Giulia Collodel, Elena Moretti, Caterina Marcucci, Laura Liguori, Daniela Marchini, Roberta Corsaro, Gabriele Centini, Cinzia Signorini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giulia CollodelDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-1587-0159
Elena MorettiDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9467-0501
Caterina MarcucciDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0009-0003-5682-4148
Laura LiguoriDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0009-0008-5563-236X
Daniela MarchiniDepartment of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-8380-7453
Roberta CorsaroDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9091-8952
Gabriele CentiniDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-6113-7401
Cinzia SignoriniDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0006-9414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a regulating agent in antioxidant response also involved in controlling inflammation. The impact of varicocele and urogenital infections on sperm PPARγ expression was studied. The PPARγ gene expression was investigated in spermatozoa of 26 normozoospermic men grouped according to their clinical conditions: normal semen parameters (N), normal semen parameters and varicocele (N + V), and normal semen parameters and urogenital infections (N + UI). Sperm PPARγ expression was correlated with F

Indexed as

F2-isoprostaneshuman spermatozoanormozoospermiaPPARγ expressionresolvin D1urogenital infectionsvaricocele

Identifiers

PMID40001905
PMCPMC11851876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.