Evidence map›Paper›PMID 40001699›Full record

ArticleBioengineering (Basel, Switzerland)2025

A Conceptual Framework for Applying Ethical Principles of AI to Medical Practice.

Debesh Jha, Gorkem Durak, Vanshali Sharma, Elif Keles, Vedat Cicek, Zheyuan Zhang, Abhishek Srivastava, Ashish Rauniyar, Desta Haileselassie Hagos, Nikhil Kumar Tomar and 5 more

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Debesh JhaMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Gorkem DurakMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-1608-1955
Vanshali SharmaMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-0008-1579
Elif KelesMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Vedat CicekMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Zheyuan ZhangMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Abhishek SrivastavaMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Ashish RauniyarSustainable Communication Technologies, SINTEF Digital, 7034 Trondheim, Norway.ORCID 0000-0002-2142-9522
Desta Haileselassie HagosDepartment of Electrical Engineering and Computer Science, Howard University, Washington, DC 20059, USA.
Nikhil Kumar TomarMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Frank H MillerMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
Ahmet TopcuDepartment of General Surgery, Tokat State Hospital, Tokat 60100, Türkiye.
Anis YazidiOsloMet Artificial Intelligence (AI) Lab, Oslo Metropolitan University, 0130 Oslo, Norway.ORCID 0000-0001-7591-1659
Jan Erik HåkegårdSustainable Communication Technologies, SINTEF Digital, 7034 Trondheim, Norway.ORCID 0000-0003-4329-1410
Ulas BagciMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, IL 60611, USA.

Funding

Cyst-X: Interpretable Deep Learning Based Risk Stratification of Pancreatic Cystic TumorsR01CA246704 · NCI · UNIVERSITY OF CENTRAL FLORIDA · PI BAGCI, ULAS · 2020 to 2024
$2.4M
Radiologist-Centered Artificial Intelligence (RCAI) for Lung Cancer Screening and DiagnosisR01CA240639 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BAGCI, ULAS · 2020 to 2024
$2.0M
NCI NIH HHS R01 CA240639NCI NIH HHS R01 CA246704NIH HHS R01-CA246704 and R01-CA240639.Wellcome Trust 300102
6 · The paper itself

Abstract

Artificial Intelligence (AI) is reshaping healthcare through advancements in clinical decision support and diagnostic capabilities. While human expertise remains foundational to medical practice, AI-powered tools are increasingly matching or exceeding specialist-level performance across multiple domains, paving the way for a new era of democratized healthcare access. These systems promise to reduce disparities in care delivery across demographic, racial, and socioeconomic boundaries by providing high-quality diagnostic support at scale. As a result, advanced healthcare services can be affordable to all populations, irrespective of demographics, race, or socioeconomic background. The democratization of such AI tools can reduce the cost of care, optimize resource allocation, and improve the quality of care. In contrast to humans, AI can potentially uncover complex relationships in the data from a large set of inputs and generate new evidence-based knowledge in medicine. However, integrating AI into healthcare raises several ethical and philosophical concerns, such as bias, transparency, autonomy, responsibility, and accountability. In this study, we examine recent advances in AI-enabled medical image analysis, current regulatory frameworks, and emerging best practices for clinical integration. We analyze both technical and ethical challenges inherent in deploying AI systems across healthcare institutions, with particular attention to data privacy, algorithmic fairness, and system transparency. Furthermore, we propose practical solutions to address key challenges, including data scarcity, racial bias in training datasets, limited model interpretability, and systematic algorithmic biases. Finally, we outline a conceptual algorithm for responsible AI implementations and identify promising future research and development directions.

Indexed as

artificial intelligence (AI)ethical AIphilosophical AItrustworthy AI

Identifiers

PMID40001699
PMCPMC11851997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.