Evidence map›Paper›PMID 40001695›Full record

ReviewBioengineering (Basel, Switzerland)2025

Challenges and Opportunities in Cytopathology Artificial Intelligence.

Meredith A VandeHaar, Hussien Al-Asi, Fatih Doganay, Ibrahim Yilmaz, Heba Alazab, Yao Xiao, Jagadheshwar Balan, Bryan J Dangott, Aziza Nassar, Jordan P Reynolds and 1 more

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A Unified Deep Learning Framework for Instance Segmentation Across Diverse Cytological Stains.Cytopathology : official journal of the British Society for Clinical Cytology · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meredith A VandeHaarCytology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0000-9142-8587
Hussien Al-AsiComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0003-5681-0600
Fatih DoganayComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Ibrahim YilmazComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Heba AlazabComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Yao XiaoComputational Biology, Quantitative Health Science, Mayo Clinic, Rochester, MN 55905, USA.
Jagadheshwar BalanComputational Biology, Quantitative Health Science, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-8291-4054
Bryan J DangottComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Aziza NassarComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-6678-9329
Jordan P ReynoldsComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Zeynettin AkkusComputational Pathology and Artificial Intelligence, Department of Laboratory Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3920-1515

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial Intelligence (AI) has the potential to revolutionize cytopathology by enhancing diagnostic accuracy, efficiency, and accessibility. However, the implementation of AI in this field presents significant challenges and opportunities. This review paper explores the current landscape of AI applications in cytopathology, highlighting the critical challenges, including data quality and availability, algorithm development, integration and standardization, and clinical validation. We discuss challenges such as the limitation of only one optical section and z-stack scanning, the complexities associated with acquiring high-quality labeled data, the intricacies of developing robust and generalizable AI models, and the difficulties in integrating AI tools into existing laboratory workflows. The review also identifies substantial opportunities that AI brings to cytopathology. These include the potential for improved diagnostic accuracy through enhanced detection capabilities and consistent, reproducible results, which can reduce observer variability. AI-driven automation of routine tasks can significantly increase efficiency, allowing cytopathologists to focus on more complex analyses. Furthermore, AI can serve as a valuable educational tool, augmenting the training of cytopathologists and facilitating global health initiatives by making high-quality diagnostics accessible in resource-limited settings. The review underscores the importance of addressing these challenges to harness the full potential of AI in cytopathology, ultimately improving patient care and outcomes.

Indexed as

artificial intelligencecytopathologydeep learningrapid onsite evaluation

Identifiers

PMID40001695
PMCPMC11851434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.