ArticleBioengineering (Basel, Switzerland)2025
Comparison Between Micro- and Micro-Nano Surface Texturization in the Initial Osseointegration Process: An Experimental In Vitro and In Vivo Preclinical Study.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Biomechanical behavior of two different surface treatments on dental implants with healing chambers in osteoporotic rabbits: an experimental study.Scientific reports · 2025Article
- Early Osseointegration in a Sheep Tibia Model: Correlating Digital Periapical Radiograph Gray-Level and RGB-Derived Metrics with Histologic Tissue Composition.Journal of functional biomaterials · 2025Article
- Residual-Free Micro-Nano Titanium Surfaces via Titanium Blasting and Single Acid-Etching: A Cleaner Alternative.Bioengineering (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe physicochemical changes of the surface aim to improve cell adhesion, proliferation, and differentiation, that is, better biological interaction with the cells and, consequently, with the peri-implant tissues. In the present study, implants with the same macrogeometry were compared in vitro and in vivo, but with two different surfaces: micro-rough and a new micro-nano-rough surface. MATERIALS AND
methodsA total of 90 implants were used, 10 of which were used for in vitro surface characterization (n = 5 per group) through scanning electron microscopy (SEM), atomic force microscopy (AFM), and surface roughness measurements. For in vivo tests, 80 implants (n = 40 per group) were used in 20 rabbits (n = 2 implants per tibia). Two experimental groups were created: a control group, where the implants had a surface treated by sandblasting with titanium oxide microparticles, and a test group, where the implants were sandblasted using the same process as the previous group plus acid conditioned. The implant stability quotient (ISQ) was measured by resonance frequency (initially and at both euthanasia times). Animals were euthanized 3 and 5 weeks after implantation (n = 10 animals per time). Ten samples from each group at each time point were evaluated by removal torque (RTv). Another ten samples from each group were evaluated histologically and histomorphometrically, measuring the percentage of bone-to-implant contact (%BIC) and the bone area fraction occupancy (%BAFO).
resultsIn vitro, it was possible to observe a more homogeneous surface for the test group compared to the control group. ISQ values showed statistical differences at both 3 and 5 weeks (test > control). For RTv, the values were: 44.5 ± 4.25 Ncm (control group) and 48.6 ± 3.17 Ncm (test group) for the time of 3 weeks; 64.3 ± 4.50 Ncm (control group) and 76.1 ± 4.18 Ncm (test group) at 5 weeks. The %BIC and %BAFO values measured in both groups and at both times did not show significant differences (
conclusionsThe higher removal torque and ISQ values presented in the samples from the test group compared to the control group indicate that there was an acceleration in the mineralization process of the newly formed bone matrix.
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