Evidence map›Paper›PMID 40001606›Full record

ArticleBiomolecules2025

Omics Investigations of Prostate Cancer Cells Exposed to Simulated Microgravity Conditions.

Herbert Schulz, Fatima Abdelfattah, Anna Heinrich, Daniela Melnik, Viviann Sandt, Marcus Krüger, Markus Wehland, Per Hoffmann, José Luis Cortés-Sánchez, Matthias Evert and 2 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Epigenetics in Space: The Dynamic Cellular Response.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Herbert SchulzDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0002-0226-964X
Fatima AbdelfattahDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0002-4488-1431
Anna HeinrichDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.
Daniela MelnikDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.
Viviann SandtDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.
Marcus KrügerDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0003-1120-0246
Markus WehlandDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0002-8160-859X
Per HoffmannInstitute of Human Genetics, University Hospital of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-6573-983X
José Luis Cortés-SánchezResearch Group "Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt- und Schwerelosigkeitsbedingungen" (MARS), Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0002-4646-9520
Matthias EvertInstitute for Pathology, University Regensburg, 93053 Regensburg, Germany.
Katja EvertInstitute for Pathology, University Regensburg, 93053 Regensburg, Germany.ORCID 0000-0003-0984-5563
Daniela GrimmDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0002-4991-3105

Funding

German Space Agency (Deutsches Zentrum für Luft- und Raumfahrt; DLR) BMWi 50WB2219German Space Agency (Deutsches Zentrum für Luft- und Raumfahrt; DLR) BMWi 50WK2270G
6 · The paper itself

Abstract

Prostate cancer (PC) is the most diagnosed cancer in males across the globe. Following the formation of metastasis, PC is linked to a notable decline in both prognosis and survival rates. Three-dimensional multicellular spheroids (MCSs) of a prostate adenocarcinoma cell line were generated in a three-day simulated microgravity environment (s-µ

Indexed as

Prostatic NeoplasmsWeightlessness SimulationCell Line, TumorDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMaleSpheroids, Cellularcell cultureDNA methylationfibronectingene expressionomicsprostate cancerrandom positioning machinesimulated microgravity

Identifiers

PMID40001606
PMCPMC11853236

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.