Evidence map›Paper›PMID 40001602›Full record

ArticleBiomolecules2025

RORA Regulates Autophagy in Hair Follicle Stem Cells by Upregulating the Expression Level of the

Xuefei Zhao, Yanchun Xu, Shuqi Li, Suying Bai, Wei Zhang, Yu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuefei ZhaoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0002-7368-0057
Yanchun XuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Shuqi LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Suying BaiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0001-9686-3342
Wei ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yu ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0002-1615-7382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hair coat is an adaptive evolutionary trait unique to mammals, aiding them in adapting to complex environmental challenges. Although some of the factors involved in regulating hair follicle development have been characterized, further in-depth research is still needed. Retinoic acid receptor-related orphan receptor alpha (RORA), as a member of the nuclear receptor family, is highly involved in the regulation of cellular states. Previous studies have shown that autophagy plays a significant role in hair follicle development. This study uses rat hair follicle stem cells (HFSCs) as a model to analyze the impact of RORA on the autophagy levels of HFSCs. Upon activation of RORA, autophagy indicators such as the LC3-II/LC3-I ratio and MDC staining significantly increased, suggesting an elevated level of autophagy in HFSCs. Following treatment with chloroquine, the LC3-II/LC3-I ratio, as well as the expression levels of BECN1 protein and SQSTM1 protein, were markedly elevated in the cells, indicating that the autophagic flux was unobstructed and ruling out the possibility that RORA activation impeded autophagy. Additionally, the level of the

Indexed as

AutophagyHair FollicleSequestosome-1 ProteinStem CellsAnimalsCells, CulturedRatsRats, Sprague-DawleyUp-RegulationSequestosome-1 ProteinSqstm1 protein, ratautophagyhair folliclehair follicle stem cellsRORASqstm1

Identifiers

PMID40001602
PMCPMC11853448

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.