Evidence map›Paper›PMID 40001567›Full record

ArticleBiomolecules2025

New Insights on the miRNA Role in Diabetic Tendinopathy: Adipose-Derived Mesenchymal Stem Cell Conditioned Medium as a Potential Innovative Epigenetic-Based Therapy for Tendon Healing.

Marina Russo, Caterina Claudia Lepre, Gianluca Conza, Nicoletta Tangredi, Giovanbattista D'Amico, Adriano Braile, Antimo Moretti, Umberto Tarantino, Francesca Gimigliano, Michele D'Amico and 2 more

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In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marina RussoDepartment of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-2011-6353
Caterina Claudia LepreDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-9041-1043
Gianluca ConzaDepartment of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0009-0003-7621-4013
Nicoletta TangrediDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giovanbattista D'AmicoSchool of Geriatrics, University of Studies of L'Aquila, 67010 L'Aquila, Italy.
Adriano BraileDepartment of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-5366-5733
Antimo MorettiDepartment of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-4598-2891
Umberto TarantinoDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-0330-2189
Francesca GimiglianoDepartment of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Michele D'AmicoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-6899-0595
Maria Consiglia TrottaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-9813-5955
Giuseppe ToroDepartment of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-8560-721X

Funding

University of Campania "Luigi Vanvitelli" STEMBIONEC
6 · The paper itself

Abstract

backgroundAdipose-derived mesenchymal stem cell conditioned medium (ASC-CM) improved the viability and wound closure of human tenocytes (HTCN) exposed to high glucose (HG) by activating the transforming growth factor beta 1 (TGF-β1) pathway.

objectivesSince ASC-CM can also modulate microRNAs (miRNAs) in recipient cells, this study investigated the effects of ASC-CM on the miRNAs regulating tendon repair (miR-29a-3p, miR-210-3p and miR-21-5p) in HG-HTNC.

methodsASC-CM was obtained by ASCs isolated from the abdominal fat tissue of seven non-diabetic patients. HTNC were cultured in HG for 20 days, then scratched and exposed for 24 h to ASC-CM. qRT-PCR and ELISAs assessed miRNA and target levels.

resultsHG-HTNC exhibited a significant downregulation of miRNAs. ASC-CM restored the levels of miRNAs and their related targets involved in tendon repair.

conclusionsThe epigenetic modulation observed in HG-HTNC exposed to ASC-CM could be an innovative option in the management of diabetic tendinopathy.

Indexed as

Diabetes ComplicationsEpigenesis, GeneticMesenchymal Stem CellsMicroRNAsTendinopathyAdipose TissueCells, CulturedCulture Media, ConditionedFemaleGlucoseHumansMaleMiddle AgedTendonsTenocytesWound HealingCulture Media, ConditionedGlucoseMicroRNAsadipose-derived mesenchymal stem cellconditioned mediumdiabetic tendinopathymicroRNAs

Identifiers

PMID40001567
PMCPMC11852990

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